⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555632 | 1.00 | — | — | |
| SCHEMBL5195767 | 0.88 | SUCNR1 (0.42) | — | |
| SCHEMBL5608067 | 0.88 | SUCNR1 (0.42) | — | |
| SCHEMBL5194126 | 0.88 | SUCNR1 (0.42) | — | |
| SCHEMBL10359233 | 0.83 | SUCNR1 (0.37) | — | |
| SCHEMBL8539572 | 0.80 | SUCNR1 (0.62) | — | |
| SCHEMBL3495093 | 0.69 | SUCNR1 (0.42) | — | |
| SCHEMBL21541079 | 0.69 | LMNA (0.40) | — | |
| SCHEMBL15765556 | 0.68 | SUCNR1 (0.48) | — | |
| SCHEMBL4458181 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334324-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022235866-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-11-10 | — | — | WO | disclosed |
| US-7164047-B2 | Subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis in the presence of a base, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, and reducing the obtained cyclopropylacetaldehyde; low cost, industrially advantageous | KURARAY CO., LTD. (JP) | 2007-01-16 | — | — | US | disclosed |
| US-20050020846-A1 | Subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis in the presence of a base, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, and reducing the obtained cyclopropylacetaldehyde; low cost, industrially advantageous | KURARAY CO., LTD. (JP) | 2005-01-27 | — | — | US | disclosed |
| EP-1445248-A1 | PROCESSES FOR PREPARATION OF CYCLOPROPYLETHANOL, CYCLO-PROPYLACETONITRILE AND INTERMEDIATES OF BOTH | KURARAY CO., LTD. (JP) | 2004-08-11 | — | — | EP | disclosed |
| JP-2003306471-A | METHOD FOR PRODUCING 2-CYCLOPROPYLETHYLAMINE | KURARAY CO LTD | 2003-10-28 | — | — | JP | disclosed |
| JP-2003206247-A | METHOD OF PRODUCING CYCLOPROPYLETHANOL | KURARAY CO LTD | 2003-07-22 | — | — | JP | disclosed |