Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049590 | 0.81 | MAP4K1 (0.41) | SMN1; SMN2TSHRMAP4K1NPSR1LMNA | |
| SCHEMBL1673497 | 0.81 | SLC6A3 (0.47) | PRCPKDM1AMAP4K1LMNAALDH1A1 | |
| SCHEMBL380027 | 0.81 | TDP1 (0.50) | SMN1; SMN2PRCPMAPTKDM1AMAP4K1 | |
| SCHEMBL9786155 | 0.81 | TDP1 (0.50) | SMN1; SMN2PRCPMAPTKDM1AMAP4K1 | |
| SCHEMBL17055320 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTKDM1AMAP4K1RAB9A | |
| SCHEMBL10373386 | 0.80 | GID4 (0.49) | SMN1; SMN2GID4MAPTKDM1ARAB9A | |
| SCHEMBL26986647 | 0.80 | PRCP (0.44) | PRCPGID4MAPTKDM1AMAP4K1 | |
| SCHEMBL596560 | 0.80 | PRCP (0.44) | PRCPGID4MAPTKDM1AMAP4K1 | |
| SCHEMBL6996372 | 0.77 | L3MBTL1 (0.48) | MAPTKDM1AMAP4K1MEN1KMT2A | |
| SCHEMBL5543742 | 0.77 | TSHR (0.41) | SMN1; SMN2TSHRMAPTMAP4K1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168658-B2 | Inhibitors of histone deacetylase | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| WO-2010107605-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-09-23 | — | — | WO | disclosed |
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME LLC | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC6 | SMN1; SMN2 406/4885TSHR 1166/4885PRCP 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.