Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.63 |
| ▸ | CTSK | P43235 | 5/20 | 0.63 |
| ▸ | CTSL | P07711 | 4/20 | 0.63 |
| ▸ | CTSB | P07858 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 6/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245158 | 0.92 | CTSS (0.52) | CTSSCTSKCTSLCTSBGSK3B | |
| SCHEMBL5591423 | 0.91 | CTSS (0.76) | CTSSCTSKCTSLCTSBCHKA | |
| SCHEMBL3172737 | 0.89 | CTSS (0.59) | CTSSCTSKCTSLCTSBGSK3B | |
| SCHEMBL5591471 | 0.86 | CTSS (0.69) | CTSSCTSKCTSLCTSBKLKB1 | |
| SCHEMBL5591406 | 0.86 | CTSS (0.63) | CTSSCTSKCTSLCTSBGSK3B | |
| Trifluoroacetic Acid SCHEMBL5591441 | 0.86 | CTSS (0.69) | CTSSCTSKCTSLCTSBTBK1 | |
| Trifluoroacetic Acid SCHEMBL3159660 | 0.85 | CTSS (0.55) | CTSSCTSKCTSLCTSBGSK3B | |
| SCHEMBL5591180 | 0.85 | CTSS (0.68) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL5590944 | 0.85 | CTSS (0.68) | CTSSCTSKCTSLCTSBTBK1 | |
| SCHEMBL5591415 | 0.85 | CTSS (0.67) | CTSSCTSKCTSLCTSBKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007025774-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | claimed |
| WO-2007025774-A2 | CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |