Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5609833 | 0.88 | LMNA (0.42) | NOTUMSMARCA2SMARCA4PBRM1MAPK13 | |
| SCHEMBL22033127 | 0.81 | NOTUM (0.45) | NOTUMARLMNAFFAR1FFAR4 | |
| SCHEMBL5615724 | 0.77 | LMNA (0.46) | NOTUMARMAPK13MAPK12MAPK11 | |
| SCHEMBL5591514 | 0.77 | ALDH1A1 (0.48) | LMNATP53CYP3A4ALDH1A1 | |
| SCHEMBL5406790 | 0.76 | CHRNB2 (0.55) | NOTUMARMAPK13MAPK12MAPK11 | |
| SCHEMBL17796820 | 0.76 | SMPD3 (0.43) | SMARCA2SMARCA4PBRM1SMPD3IKBKB | |
| SCHEMBL17796769 | 0.76 | SMPD3 (0.43) | SMARCA2SMARCA4PBRM1SMPD3IKBKB | |
| SCHEMBL15651663 | 0.76 | MAPT (0.53) | SMARCA2SMARCA4PBRM1ARSMPD3 | |
| SCHEMBL15652154 | 0.76 | MAPT (0.53) | SMARCA2SMARCA4PBRM1ARSMPD3 | |
| SCHEMBL2019193 | 0.76 | MAPT (0.53) | SMARCA2SMARCA4PBRM1ARSMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |