Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5615724 | 0.93 | LMNA (0.46) | LMNAALDH1A1MAPTMAPK1NOTUM | |
| SCHEMBL5591766 | 0.88 | NOTUM (0.44) | LMNAALDH1A1NOTUMMAPK13MAPK12 | |
| SCHEMBL5598315 | 0.82 | MAPT (0.50) | LMNAALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL22032842 | 0.77 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTMAPK1NOTUM | |
| SCHEMBL13421452 | 0.76 | LMNA (0.43) | LMNAALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL2018527 | 0.74 | MAPT (0.61) | LMNAALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL16651521 | 0.74 | MAPT (0.61) | LMNAALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL5598235 | 0.74 | MAPT (0.59) | LMNAALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL5065287 | 0.71 | LMNA (0.68) | LMNAALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL22033127 | 0.71 | NOTUM (0.45) | LMNAALDH1A1MAPTNOTUML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |