SCHEMBL5592991

SCHEMBL5592991

NNc1cccc2nc3ccccc3cc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.59
ALDH1A1 P00352 5/20 0.59
KDM4E B2RXH2 5/20 0.59
GAA P10253 5/20 0.59
GLA P06280 4/20 0.59
HPGD P15428 4/20 0.59
RAB9A P51151 4/20 0.59
LMNA P02545 2/20 0.59
POLB P06746 2/20 0.59
NPC1 O15118 1/20 0.59
PTBP1 P26599 1/20 0.59
RCE1 Q9Y256 1/20 0.59
MAPT P10636 5/20 0.50
ACHE P22303 2/20 0.50
HTR3A P46098 1/20 0.43
KDM1A O60341 2/20 0.42
IDO1 P14902 1/20 0.41
NQO2 P16083 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
CASP1 P29466 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9415823 0.85 KDM4E (0.58) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL17066283 0.83 HTR3A (0.54) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL6679710 0.81 ALDH1A1 (0.55) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL27791326 0.81 KMT2A (0.55) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL4939236 0.80 ALDH1A1 (0.61) KMT2AALDH1A1KDM4EGAAGLA
Hydrochloric Acid SCHEMBL15673453 0.79 ALDH1A1 (0.59) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL625847 0.78 ALDH1A1 (0.67) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL27860753 0.77 KMT2A (0.50) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL617157 0.77 ALDH1A1 (0.65) KMT2AALDH1A1KDM4EGAAGLA
SCHEMBL6626253 0.76 ALDH1A1 (0.59) KMT2AALDH1A1KDM4EGAAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007104695-A1 QUINOLIN-4-YLHYDRAZINE DERIVATIVES AS ANTIMALARIAL AGENT SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2007-09-20 WO claimed
WO-2007104695-A1 QUINOLIN-4-YLHYDRAZINE DERIVATIVES AS ANTIMALARIAL AGENT SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2007-09-20 WO disclosed
WO-2007104695-A1 QUINOLIN-4-YLHYDRAZINE DERIVATIVES AS ANTIMALARIAL AGENT SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) 2007-09-20 WO disclosed