Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | GAA | P10253 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617157 | 0.98 | ALDH1A1 (0.65) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL27791326 | 0.78 | KMT2A (0.55) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL5592991 | 0.78 | KMT2A (0.59) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL9415823 | 0.78 | KDM4E (0.58) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL260429 | 0.78 | KDM4E (0.71) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL29522175 | 0.78 | KDM4E (0.71) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| Hydrogen Sulfide SCHEMBL27456819 | 0.76 | KDM4E (0.69) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| Hydrazine SCHEMBL28848708 | 0.76 | KDM4E (0.69) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL27567335 | 0.76 | KDM4E (0.69) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL23143652 | 0.76 | KDM4E (0.45) | ALDH1A1GAAKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299299-A | The third amino of 4- -1,8- naphthalimide -7- benzos [c] acridine thiocarbamide and its preparation method and application | 广西中医药大学 | 2018-07-20 | — | — | CN | claimed |
| CN-108299299-B | 4-propylamino-1, 8-naphthalimide-7-benzo [ c ] acridine thiourea and preparation method and application thereof | 广西中医药大学 | 2021-04-20 | — | — | CN | disclosed |
| CN-108299299-B | 4-propylamino-1, 8-naphthalimide-7-benzo [ c ] acridine thiourea and preparation method and application thereof | 广西中医药大学 | 2021-04-20 | — | — | CN | disclosed |
| CN-108299299-A | The third amino of 4- -1,8- naphthalimide -7- benzos [c] acridine thiocarbamide and its preparation method and application | 广西中医药大学 | 2018-07-20 | — | — | CN | disclosed |
| CN-108299299-A | The third amino of 4- -1,8- naphthalimide -7- benzos [c] acridine thiocarbamide and its preparation method and application | 广西中医药大学 | 2018-07-20 | — | — | CN | disclosed |
| CN-108299299-A | The third amino of 4- -1,8- naphthalimide -7- benzos [c] acridine thiocarbamide and its preparation method and application | 广西中医药大学 | 2018-07-20 | — | — | CN | disclosed |
| CN-105412108-B | 2- methoxyl group -9- acridines（To methoxy benzamide base）Application of the thiocarbamide in acetylcholinesterase inhibitor is prepared | 广西中医药大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-105476992-B | Application of the 2- methoxyl group -9- acridine benzamido thiocarbamides in acetylcholinesterase inhibitor is prepared | 广西中医药大学 | 2018-07-06 | — | — | CN | disclosed |
| CN-105476992-A | Application of 2-methoxy-9-acridine benzamido thiourea in preparation of acetylcholinesterase inhibitor | UNIV GUANGXI CHINESE MEDICINE | 2016-04-13 | — | — | CN | disclosed |
| CN-105412108-A | Application of 2-methoxy-9-acridine(4-methoxybenzamido) thiourea to preparing of acetylcholin esterase inhibitor | UNIV GUANGXI CHINESE MEDICINE | 2016-03-23 | — | — | CN | disclosed |
| US-9090640-B2 | Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof | WAKE FOREST UNIVERSITY | 2015-07-28 | — | — | US | disclosed |
| US-8906896-B2 | Platinum acridine anti-cancer compounds and methods thereof | WAKE FOREST UNIVERSITY | 2014-12-09 | — | — | US | disclosed |
| US-20140193334-A1 | Targeted Delivery and Prodrug Designs for Platinum-Acridine Anti-Cancer Compounds and Methods Thereof | WAKE FOREST UNIVERSITY | 2014-07-10 | — | — | US | disclosed |
| WO-2013033430-A1 | TARGETED DELIVERY AND PRODRUG DESIGNS FOR PLATINUM-ACRIDINE ANTI-CANCER COMPOUNDS AND METHODS THEREOF | WAKE FOREST SCHOOL OF MEDICINE (US) | 2013-03-07 | — | — | WO | disclosed |
| US-20120039800-A1 | Platinum Acridine Anti-Cancer Compounds And Methods Thereof | WAKE FOREST UNIVERSITY | 2012-02-16 | — | — | US | disclosed |
| EP-2358203-A1 | PLATINUM ACRIDINE ANTI-CANCER COMPOUNDS AND METHODS THEREOF | Wake Forest University (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010048499-A1 | PLATINUM ACRIDINE ANTI-CANCER COMPOUNDS AND METHODS THEREOF | WAKE FOREST UNIVERSITY (US) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120039800-A1 | Platinum Acridine Anti-Cancer Compounds And Methods Thereof | ACR, TP53, BAD | ALDH1A1 360/4885GAA 1830/4885KDM4E 3597/4885 |
| US-20140193334-A1 | Targeted Delivery and Prodrug Designs for Platinum-Acridine Anti-Cancer Compounds and Methods Thereof | ERBB3, EGFR, ESR1 | ALDH1A1 2873/4885GAA 2626/4885KDM4E 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.