Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22437378 | 0.80 | ALDH1A1 (0.38) | POLBHTTALDH1A1KMT2ARAB9A | |
| SCHEMBL16181780 | 0.79 | POLB (0.43) | POLBHTTALDH1A1KMT2AHSP90AA1 | |
| SCHEMBL11722261 | 0.75 | ERN1 (0.46) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5592987 | 0.74 | NOS3 (0.36) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL16975394 | 0.73 | ALDH1A1 (0.56) | POLBHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL3942261 | 0.73 | ALDH1A1 (0.50) | HTTALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL29606539 | 0.73 | ALDH1A1 (0.50) | HTTALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL21591671 | 0.73 | ALDH1A1 (0.34) | HTTALDH1A1KMT2AMEN1SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL27652614 | 0.72 | ALDH1A1 (0.48) | HTTALDH1A1KMT2AHSP90AA1CXCR5 | |
| SCHEMBL3934740 | 0.72 | ALDH1A1 (0.50) | POLBHTTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710435-A1 | OX1 ANTAGONISTS | Heptares Therapeutics Limited (GB) | 2020-09-23 | — | — | EP | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |