Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065908 | 0.83 | AURKA (0.50) | TTRJAK2RPS6KA3MELKSTK24 | |
| SCHEMBL8077141 | 0.81 | AURKA (0.45) | TTRJAK2RPS6KA3MELKSTK24 | |
| SCHEMBL10797668 | 0.78 | TTR (0.46) | TTRAURKAAURKBALDH1A1HSD17B10 | |
| SCHEMBL28118203 | 0.73 | AURKA (0.44) | TTRJAK2RPS6KA3MELKSTK24 | |
| SCHEMBL4763755 | 0.73 | TTR (0.46) | TTRJAK2RPS6KA3MELKSTK24 | |
| SCHEMBL625075 | 0.73 | FABP4 (0.63) | TTRALDH1A1HSD17B10TSHRTDP1 | |
| SCHEMBL29360969 | 0.73 | TTR (0.58) | TTRJAK2RPS6KA3MELKSTK24 | |
| SCHEMBL179823 | 0.73 | TTR (0.58) | TTRJAK2RPS6KA3MELKSTK24 | |
| Water SCHEMBL7765550 | 0.72 | TTR (0.56) | TTRJAK2RPS6KA3MELKSTK24 | |
| SCHEMBL21240726 | 0.72 | TTR (0.56) | TTRJAK2RPS6KA3MELKSTK24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814598-A2 | CONTRAST AGENTS TO TARGET EXTRACELLULAR MATRIX | GE Healthcare AS (NO) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006054904-A2 | CONTRAST AGENTS TO TARGET EXTRACELLULAR MATRIX | GE HEALTHCARE AS (NO) | 2006-05-26 | — | — | WO | disclosed |