Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | POLA1 | P09884 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15167421 | 1.00 | GAA (0.54) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL9674490 | 0.79 | LMNA (0.38) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL7238928 | 0.79 | CASP1 (0.39) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL4534469 | 0.79 | CASP1 (0.39) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL16867605 | 0.79 | GAA (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL4534473 | 0.79 | CASP1 (0.39) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL11378100 | 0.79 | GAA (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL7238935 | 0.79 | CASP1 (0.39) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL9672488 | 0.78 | ALDH1A1 (0.49) | GAAALDH1A1HCAR2GSK3BLMNA | |
| SCHEMBL4464742 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007086076-A2 | AN IMPROVED PROCESS FOR PREPARATION OF LEFLUNOMIDE | UNICHEM LABORATORIES LIMITED (IN) | 2007-08-02 | — | — | WO | claimed |
| CN-116396221-B | Preparation method of 1- (3-hydroxy-3-methyl-2-butyl) -5-methyl-1H-pyrazole-4-carboxylic acid | 无锡科华生物科技有限公司 | 2024-09-10 | — | — | CN | disclosed |
| CN-118206533-A | N-pyridazine pyrazole amide compounds | 湖南化工研究院有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-116396221-A | Preparation method of 1- (3-hydroxy-3-methyl-2-butyl) -5-methyl-1H-pyrazole-4-carboxylic acid | 无锡科华生物科技有限公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-105899508-B | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2017-07-04 | — | — | CN | disclosed |
| US-9150555-B2 | Amide derivative and use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20130211075-A1 | AMIDE DERIVATIVE AND USE THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-08-15 | — | — | US | disclosed |
| WO-2007086076-A2 | AN IMPROVED PROCESS FOR PREPARATION OF LEFLUNOMIDE | UNICHEM LABORATORIES LIMITED (IN) | 2007-08-02 | — | — | WO | disclosed |
| EP-1257270-B1 | A METHOD FOR SYNTHESIZING LEFLUNOMIDE | TEVA PHARMA (IL) | 2005-04-13 | — | — | EP | disclosed |
| EP-1473035-A1 | Leflunomide of high purity | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-11-03 | — | — | EP | disclosed |
| US-4741764-A | SUPPRESSION OF NITRIFICATION OF AMMONIUM NITROGEN IN THE SOIL | THE DOW CHEMICAL COMPANY (US) | 1988-05-03 | — | — | US | disclosed |
| US-4740233-A | Substituted 1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil | THE DOW CHEMICAL COMPANY (US) | 1988-04-26 | — | — | US | disclosed |
| EP-0259972-A2 | Heterocyclic propene amide derivatives, processes for their preparation and their use as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1988-03-16 | — | — | EP | disclosed |
| EP-0257882-A1 | N-Phenyl butenamides with pharmaceutical properties | LILLY INDUSTRIES LIMITED (GB) | 1988-03-02 | — | — | EP | disclosed |
| US-4657919-A | CARDIOVASCULAR DISORDERS | E. I. DU PONT DE NEMOURS & CO. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4555517-A | Pyridone esters as inotropic agents | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-11-26 | — | — | US | disclosed |
| EP-0142152-A2 | Novel substituted 1,2,4-triazolo- [1,5-a] pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation and suppressing the nitrification of ammonium nitrogen in soil | THE DOW CHEMICAL COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |
| US-4468353-A | Method of preparing alkoxymethylene compounds | DYNAMIT NOBEL AG (DE) | 1984-08-28 | — | — | US | disclosed |
| US-4277418-A | Method of preparing alkoxymethylene compounds | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |
| US-3933823-A | CNS DEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130211075-A1 | AMIDE DERIVATIVE AND USE THEREOF | IL2, IL4, IL5 | GAA 1466/4885MGAM 3208/4885SI 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.