Bicarbonate

Bicarbonate

SCHEMBL5594325

O=C(O)O.ON1CCCCC1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BIMPA1

The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
CYP1A2 P05177 1/20 0.37
MAPK1 P28482 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HPGD P15428 3/20 0.36
MMP1 P03956 1/20 0.36
MMP2 P08253 1/20 0.36
MMP3 P08254 1/20 0.36
MMP9 P14780 1/20 0.36
CA2 P00918 2/20 0.35
GAA P10253 1/20 0.35
CHKA P35790 1/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 2/20 0.33
DPP7 Q9UHL4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CA1 P00915 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL29101711 0.88 FFAR3 (0.41) ALDH1A1CYP1A2MAPK1SMN1; SMN2HPGD
Carbamic Acid SCHEMBL28889871 0.88 ACHE (0.41) ALDH1A1CYP1A2MAPK1SMN1; SMN2HPGD
SCHEMBL41331 0.86
SCHEMBL18843393 0.86 ALDH1A1 (0.37) ALDH1A1CYP1A2MAPK1HPGDMMP1
SCHEMBL1360 0.86
SCHEMBL2250577 0.86
SCHEMBL739326 0.86
Maleic Acid SCHEMBL27727045 0.83 TSHR (0.47) ALDH1A1SMN1; SMN2GAAHTT
Succinic Acid SCHEMBL27958924 0.83 SMN1; SMN2 (0.52) ALDH1A1CYP1A2MAPK1SMN1; SMN2POLB
Bromide SCHEMBL2734598 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3912798-B2 2007-05-09 JP claimed
EP-0871653-B1 NOVEL AMINO ACID DERIVATIVES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOUNDS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM PHARMA (DE) 2003-03-26 EP claimed
EP-0979827-A1 Peptides having tachykinin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same Boehringer Ingelheim Pharma KG (DE) 2000-02-16 EP claimed
JP-2000501382-A 2000-02-08 JP claimed
EP-0610487-B1 NEW AMINOACID DERIVATES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM PHARMA (DE) 1999-11-10 EP claimed
EP-0871653-A1 NOVEL AMINO ACID DERIVATIVES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOUNDS CONTAINING THESE COMPOUNDS Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 1998-10-21 EP claimed
JP-2801087-B2 1998-09-21 JP claimed
EP-0804463-A1 NEUROKININE (TACHYKININE) ANTAGONISTS BOEHRINGER INGELHEIM KG (DE) 1997-11-05 EP claimed
EP-0802922-A1 NOVEL AMINO ACID DERIVATIVES, METHOD OF PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1997-10-29 EP claimed
WO-1997017362-A1 NOVEL AMINO ACID DERIVATIVES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOUNDS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1997-05-15 WO claimed
WO-1995030687-A1 NEUROKININE (TACHYKININE) ANTAGONISTS BOEHRINGER INGELHEIM KG (DE) 1995-11-16 WO claimed
WO-1995023810-A1 NOVEL AMINO ACID DERIVATIVES, METHOD OF PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1995-09-08 WO claimed
EP-0394989-B1 Peptide compounds, process for preparation thereof and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO (JP) 1994-12-21 EP claimed
EP-0610487-A1 NEW AMINOACID DERIVATES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1994-08-17 EP claimed
WO-1994005693-A1 NEW AMINOACID DERIVATES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1994-03-17 WO claimed
EP-0871653-B1 NOVEL AMINO ACID DERIVATIVES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOUNDS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM PHARMA (DE) 2003-03-26 EP disclosed
EP-0979827-A1 Peptides having tachykinin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same Boehringer Ingelheim Pharma KG (DE) 2000-02-16 EP disclosed
WO-1995023810-A1 NOVEL AMINO ACID DERIVATIVES, METHOD OF PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1995-09-08 WO disclosed
EP-0610487-A1 NEW AMINOACID DERIVATES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1994-08-17 EP disclosed
WO-1994005693-A1 NEW AMINOACID DERIVATES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS BOEHRINGER INGELHEIM KG (DE) 1994-03-17 WO disclosed