Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27500469 | 0.83 | ESR1 (0.31) | ESR1 | |
| SCHEMBL6826215 | 0.83 | ALB (0.38) | ESR1MAPK11MAPK14 | |
| SCHEMBL27519344 | 0.83 | CXCR2 (0.37) | ESR1MAPK14CXCR1CXCR2 | |
| SCHEMBL27519456 | 0.82 | MMP2 (0.44) | MMP2ALOX15 | |
| SCHEMBL27516293 | 0.80 | KDM4E (0.38) | ESR1ALOX15TSHRCXCR1CXCR2 | |
| SCHEMBL27535605 | 0.80 | SMN1; SMN2 (0.39) | ESR1 | |
| SCHEMBL6825645 | 0.80 | CXCR2 (0.39) | TSHRCXCR1CXCR2 | |
| SCHEMBL27566072 | 0.79 | GPR35 (0.47) | CXCR1CXCR2 | |
| SCHEMBL27499546 | 0.78 | ALDH1A1 (0.32) | ESR1 | |
| SCHEMBL27587734 | 0.78 | CXCR2 (0.45) | ESR1TSHRCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809492-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2007-01-24 | — | — | EP | disclosed |
| CN-1539816-A | IL-8 receptor antagonists | ʷ��˿�������ȳ�ķ����˾ | 2004-10-27 | — | — | CN | disclosed |
| CN-1355697-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | CN | disclosed |
| CN-1215990-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-05-05 | — | — | CN | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |