SCHEMBL27587734

SCHEMBL27587734

NC(=O)N(c1ccccc1Br)c1ccc(Cl)c(Cl)c1O

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 8/20 0.45
CXCR1 P25024 7/20 0.45
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
CASP1 P29466 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
CX3CR1 P49238 1/20 0.30
ESR1 P03372 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27519344 0.85 CXCR2 (0.37) CXCR2CXCR1ESR1
SCHEMBL27608152 0.84 CXCR2 (0.51) CXCR2CXCR1CX3CR1ESR1
SCHEMBL7552627 0.84 TSHR (0.36) CXCR2CXCR1HPGDTSHRCASP1
SCHEMBL27516965 0.83 CXCR2 (0.50) CXCR2CXCR1
SCHEMBL27587730 0.81 NPSR1 (0.40) CXCR2CXCR1HPGDTSHRCASP1
SCHEMBL6825106 0.80 PAX8 (0.43) HPGDKMT2AATMESR1
SCHEMBL6550852 0.79 CXCR2 (0.41) CXCR2CXCR1CX3CR1ESR1
SCHEMBL5594733 0.78 MMP2 (0.39) CXCR2CXCR1TSHRESR1
SCHEMBL27571760 0.77 CXCR2 (0.45) CXCR2CXCR1TSHRATM
SCHEMBL27499546 0.77 ALDH1A1 (0.32) ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1539816-A IL-8 receptor antagonists ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-27 CN disclosed