Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.65 |
| ▸ | TTR | P02766 | 4/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | RARB | P10826 | 1/20 | 0.54 |
| ▸ | COMT | P21964 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491761 | 0.93 | MAPK1 (0.61) | MAPK1VCAM1TTRGPR35ABCC3 | |
| SCHEMBL867944 | 0.87 | VCAM1 (0.69) | MAPK1VCAM1TTRGPR35ABCC3 | |
| SCHEMBL11014183 | 0.86 | MAPK1 (0.73) | MAPK1VCAM1TTRGPR35ABCC3 | |
| Methane SCHEMBL28199058 | 0.85 | VCAM1 (0.68) | MAPK1VCAM1TTRGPR35ABCC3 | |
| Methane SCHEMBL27604929 | 0.85 | VCAM1 (0.68) | MAPK1VCAM1TTRGPR35ABCC3 | |
| Arsenic SCHEMBL28025098 | 0.85 | VCAM1 (0.68) | MAPK1VCAM1TTRGPR35ABCC3 | |
| SCHEMBL28055599 | 0.83 | MAPK1 (0.51) | MAPK1VCAM1TTRGPR35ABCC3 | |
| SCHEMBL459609 | 0.82 | CASP6 (0.72) | GPR35PTGS2TDP1POLBL3MBTL1 | |
| SCHEMBL31011353 | 0.82 | CASP6 (0.72) | GPR35PTGS2TDP1POLBL3MBTL1 | |
| SCHEMBL5981573 | 0.82 | TSHR (0.71) | MAPK1VCAM1TDP1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110494434-A | Pyrazolo chlorobenzene based compound, its composition and its application method | HOFFMANN LA ROCHE | 2019-11-22 | — | — | CN | disclosed |
| CN-110114343-A | Pyrazolopyrimidine compound and its application method | 豪夫迈·罗氏有限公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-109970743-A | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds as JAK inhibitors | 豪夫迈·罗氏有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109890817-A | 8- (azetidin-1-yl) - [1,2,4] triazolo [1,5-a ] pyridinyl compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-109890822-A | INHIBITORS OF CELLULAR METABOLIC PROCESSES | 安吉奥斯医药品有限公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-109890829-A | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-109476638-A | Pyrazole derivatives, its composition and therapeutical uses | 豪夫迈·罗氏有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109045032-A | Aminopyridines and application method | 麦迪威森技术有限责任公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-106132950-B | Aminopyridines and methods of use | 麦迪威森技术有限责任公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-105745209-B | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | disclosed |
| US-6180675-B1 | THERAPY FOR CHEMOKINE SENSITIVE DISEASE; USING A AROMATIC (THIO)UREA COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2001-01-30 | — | — | US | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| US-6005008-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |
| CN-1215990-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-05-05 | — | — | CN | disclosed |
| US-5886044-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| US-5780483-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-14 | — | — | US | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |