Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3513447 | 0.86 | KDM4E (0.36) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL5597094 | 0.85 | HTR3A (0.42) | GAAKMT2AMEN1 | |
| SCHEMBL2322094 | 0.84 | CCNT1 (0.35) | LMNAMAPTKDM4EALDH1A1GAA | |
| SCHEMBL5801122 | 0.84 | MAPT (0.66) | LMNAMAPTALDH1A1GAAHTT | |
| SCHEMBL11101846 | 0.81 | ACHE (0.38) | LMNAMAPTKDM4EALDH1A1CYP2C19 | |
| SCHEMBL1466733 | 0.81 | ALDH1A1 (0.58) | KDM4EALDH1A1USP2SMN1; SMN2CYP3A4 | |
| SCHEMBL1110443 | 0.81 | POLB (0.41) | LMNAKDM4EALDH1A1GAAHTT | |
| SCHEMBL6293414 | 0.80 | CHRNA7 (0.40) | MAPTKDM4EGAAKMT2AMEN1 | |
| SCHEMBL6294824 | 0.80 | ACHE (0.43) | LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL5597102 | 0.80 | KDM1A (0.41) | KDM4EHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696909-B1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | SERONO LAB (CH) | 2007-11-14 | — | — | EP | claimed |
| EP-1450792-B1 | BENZAZOLE DERIVATIVES FOR THE TREATMENT OF SCLERODERMA | APPLIED RESEARCH SYSTEMS (AN) | 2006-09-27 | — | — | EP | disclosed |
| EP-1240164-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001047920-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-07-05 | — | — | WO | disclosed |