Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5596295 | 0.87 | LTA4H (0.53) | OGACYP1A2CYP2D6HDAC2HDAC6 | |
| SCHEMBL5597057 | 0.85 | HPGD (0.54) | OGAL3MBTL1KDM4EHDAC2HDAC6 | |
| SCHEMBL5413001 | 0.79 | OGA (0.50) | OGAMKNK1MKNK2L3MBTL1KDM4E | |
| SCHEMBL5596251 | 0.77 | HPGD (0.45) | OGAHDAC2HDAC6HDAC3HDAC1 | |
| SCHEMBL27537248 | 0.77 | GFER (0.38) | OGAGBA1HDAC2HDAC6HDAC3 | |
| SCHEMBL5606358 | 0.75 | TAAR1 (0.44) | L3MBTL1HDAC2HDAC6HDAC3HDAC1 | |
| SCHEMBL5596661 | 0.74 | CYP1A2 (0.55) | OGAMKNK1NPC1RAB9ACYP1A2 | |
| SCHEMBL5254394 | 0.73 | FABP1 (0.49) | HDAC2HDAC6HDAC3HDAC1 | |
| SCHEMBL1312011 | 0.72 | PKM (0.66) | OGAMKNK1MKNK2L3MBTL1KDM4E | |
| SCHEMBL5596413 | 0.71 | HRH3 (0.49) | MKNK1MKNK2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527070-B1 | AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | MERCK SERONO SA (CH) | 2013-01-09 | — | — | EP | claimed |
| EP-1696909-B1 | BENZOTHIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES | SERONO LAB (CH) | 2007-11-14 | — | — | EP | claimed |
| EP-1667995-A1 | BENZIMIDAZOLE ACETONITRILES | Applied Research Systems ARS Holding N.V. (AN) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005026155-A1 | BENZIMIDAZOLE ACETONITRILES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | disclosed |