Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1485032 | 0.85 | CRHBP (0.48) | CRHBPCRHR2KDM4ENOTUMALDH1A1 | |
| SCHEMBL10765457 | 0.79 | KCNJ5 (0.46) | CRHBPCRHR2KDM4EP2RX7ALDH1A1 | |
| SCHEMBL28402161 | 0.78 | CYP1A2 (0.56) | CRHBPCRHR2KDM4ENOTUMALDH1A1 | |
| SCHEMBL28397579 | 0.77 | KMT2A (0.41) | CRHBPCRHR2ALDH1A1MAPT | |
| SCHEMBL28401471 | 0.76 | PARP1 (0.42) | CRHBPCRHR2KDM4EALDH1A1MAPT | |
| SCHEMBL3255936 | 0.72 | NPC1 (0.53) | KDM4ENOTUMP2RX7ALDH1A1MAPT | |
| SCHEMBL22702104 | 0.71 | CYP2A6 (0.39) | CRHBPCRHR2KDM4EALDH1A1MAPT | |
| SCHEMBL17034418 | 0.71 | KCNJ5 (0.47) | CRHBPCRHR2KDM4EP2RX7ALDH1A1 | |
| SCHEMBL19234731 | 0.71 | KCNJ5 (0.42) | CRHBPCRHR2KDM4EALDH1A1MAPT | |
| SCHEMBL19961719 | 0.70 | MAPK1 (0.56) | KDM4ENOTUMALDH1A1MAPTCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2416808-A1 | IMAGING THE CENTRAL NERVOUS SYSTEM WITH PURINERGIC P2X7 RECEPTOR BINDING AGENTS | GE Healthcare UK Limited (GB) | 2012-02-15 | — | — | EP | disclosed |
| US-20120034165-A1 | IMAGING THE CENTRAL NERVOUS SYSTEM WITH PURINERGIC P2X7 RECEPTOR BINDING AGENTS | GE HEALTHCARE LIMITED (GB) | 2012-02-09 | — | — | US | disclosed |
| US-20120034165-A1 | IMAGING THE CENTRAL NERVOUS SYSTEM WITH PURINERGIC P2X7 RECEPTOR BINDING AGENTS | GE HEALTHCARE LIMITED (GB) | 2012-02-09 | — | — | US | disclosed |
| US-20120034165-A1 | IMAGING THE CENTRAL NERVOUS SYSTEM WITH PURINERGIC P2X7 RECEPTOR BINDING AGENTS | GE HEALTHCARE LIMITED (GB) | 2012-02-09 | — | — | US | disclosed |
| WO-2010115881-A1 | IMAGING THE CENTRAL NERVOUS SYSTEM WITH PURINERGIC P2X7 RECEPTOR BINDING AGENTS | GE HEALTHCARE LIMITED (GB) | 2010-10-14 | — | — | WO | disclosed |
| US-7709469-B2 | P2X7 receptor antagonists and methods of use | ABBOTT LABORATORIES (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070105842-A1 | P2X7 receptor antagonists and methods of use | ABBVIE INC. | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105842-A1 | P2X7 receptor antagonists and methods of use | P2RX7, P2RX1, P2RX3 | CRHBP 4032/4885CRHR2 880/4885KDM4E 2718/4885 |
| US-20120034165-A1 | IMAGING THE CENTRAL NERVOUS SYSTEM WITH PURINERGIC P2X7 RECEPTOR BINDING AGENTS | P2RX3, P2RX7, P2RX5 | CRHBP 1428/4885CRHR2 618/4885KDM4E 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.