Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.67 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.62 |
| ▸ | GCGR | P47871 | 3/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088050 | 0.88 | PTGS1 (0.66) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL30874320 | 0.87 | PTGS1 (0.74) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL9748575 | 0.84 | MAPK13 (0.83) | MAPK14MAPK11CSNK1A1CSNK1DMAPK13 | |
| SCHEMBL7087754 | 0.84 | PTGS2 (0.61) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL8552621 | 0.82 | PTGS2 (0.55) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL7088524 | 0.81 | PTGS1 (0.68) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL8796825 | 0.81 | PTGS2 (0.54) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL7085579 | 0.81 | PTGS2 (0.57) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL7085580 | 0.81 | PTGS2 (0.57) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 | |
| SCHEMBL9201148 | 0.80 | MAPK14 (1.00) | PTGS1PTGS2MAPK14MAPK11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1039914-A4 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RES FOUNDATION INC (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1039914-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999030721-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-06-24 | — | — | WO | disclosed |