Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | DHODH | Q02127 | 6/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059236 | 0.90 | ADORA2A (0.42) | ADORA2AADORA2BADORA1ADORA3MEN1 | |
| SCHEMBL5054303 | 0.80 | ADORA2B (0.42) | ADORA2AADORA2BADORA1ADORA3MEN1 | |
| SCHEMBL5597238 | 0.80 | ADORA3 (0.44) | ADORA2AADORA2BADORA1ADORA3MEN1 | |
| SCHEMBL1546750 | 0.75 | ADORA2B (0.52) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL6856480 | 0.69 | HCAR2 (0.54) | PARP1PDE10A | |
| SCHEMBL5779014 | 0.69 | PDE3B (0.49) | LMNAGAAPDE3BPDE3AMAPT | |
| SCHEMBL6014101 | 0.68 | ADORA2B (0.40) | ADORA2AADORA2BADORA1ADORA3MEN1 | |
| SCHEMBL1546533 | 0.67 | ADORA2B (0.54) | ADORA2AADORA2BADORA1ADORA3MEN1 | |
| SCHEMBL1546111 | 0.66 | ADORA2A (0.55) | ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL1546032 | 0.63 | ADORA2B (0.54) | ADORA2AADORA2BADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799221-A1 | METHOD OF PREVENTING AND TREATING AIRWAY REMODELING AND PULMONARY INFLAMMATION USING A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044610-A1 | METHOD OF PREVENTING AND TREATING AIRWAY REMODELING AND PULMONARY INFLAMMATION USING A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC (US) | 2006-04-27 | — | — | WO | disclosed |