Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556563 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1LMNATP53HPGD | |
| SCHEMBL7144668 | 0.81 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL5597397 | 0.81 | PTGS2 (0.50) | PTGS2PTGS1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6448449 | 0.78 | SDHB (0.52) | PTGS2PTGS1 | |
| SCHEMBL6532907 | 0.72 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL6725713 | 0.72 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7500687 | 0.72 | PTGS2 (0.67) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL11780539 | 0.70 | HPGD (0.52) | LMNATP53HPGDHTTKMT2A | |
| SCHEMBL7083971 | 0.70 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL8044562 | 0.70 | PTGS2 (0.76) | PTGS2PTGS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109553-A4 | TREATING INFLAMMATORY DISEASES OF THE HEAD AND NECK WITH CYCLOOXYGENASE-2 INHIBITORS | CORNELL RES FOUNDATION INC (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-1109553-A1 | TREATING INFLAMMATORY DISEASES OF THE HEAD AND NECK WITH CYCLOOXYGENASE-2 INHIBITORS | CORNELL RESEARCH FOUNDATION, INC. (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013685-A1 | TREATING INFLAMMATORY DISEASES OF THE HEAD AND NECK WITH CYCLOOXYGENASE-2 INHIBITORS | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-03-16 | — | — | WO | disclosed |