Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 1.00 |
| ▸ | APP | P05067 | 5/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 3/20 | 0.77 |
| ▸ | TOP2A | P11388 | 3/20 | 0.77 |
| ▸ | PTGES | O14684 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | BACE1 | P56817 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.77 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetramethoxycurcumin SCHEMBL29763200 | 1.00 | NFE2L2 (1.00) | NFE2L2APPHSD17B10MAPTTOP2A | |
| Tetramethoxycurcumin SCHEMBL29410076 | 1.00 | NFE2L2 (1.00) | NFE2L2APPHSD17B10MAPTTOP2A | |
| Tetramethoxycurcumin SCHEMBL2622436 | 1.00 | NFE2L2 (1.00) | NFE2L2APPHSD17B10MAPTTOP2A | |
| Tetramethoxycurcumin SCHEMBL29565592 | 1.00 | NFE2L2 (1.00) | NFE2L2APPHSD17B10MAPTTOP2A | |
| SCHEMBL23903026 | 0.92 | NFE2L2 (0.85) | NFE2L2APPHSD17B10MAPTTOP2A | |
| SCHEMBL3206013 | 0.92 | NFE2L2 (0.85) | NFE2L2APPHSD17B10MAPTTOP2A | |
| SCHEMBL27833798 | 0.92 | NFE2L2 (0.85) | NFE2L2APPHSD17B10MAPTTOP2A | |
| SCHEMBL12253288 | 0.92 | APP (0.91) | NFE2L2APPHSD17B10MAPTTOP2A | |
| SCHEMBL3206032 | 0.92 | NFE2L2 (0.85) | NFE2L2APPHSD17B10MAPTTOP2A | |
| SCHEMBL13039641 | 0.92 | NFE2L2 (0.84) | NFE2L2APPHSD17B10MAPTTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106093216-B | The high performance liquid chromatography test method of 11 kinds of colorants in a kind of tobacco leaf | 国家烟草质量监督检验中心 | 2018-11-06 | — | — | CN | claimed |
| CN-105012234-B | A kind of 1,7-bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione polymer micelle and preparation method thereof and medical usage | 烟台大学 | 2018-10-16 | — | — | CN | claimed |
| CN-106093216-A | The high performance liquid chromatography method of testing of 11 kinds of coloring agent in a kind of Nicotiana tabacum L. | 国家烟草质量监督检验中心 | 2016-11-09 | — | — | CN | claimed |
| US-9271493-B2 | Methods for microbial biofilm destruction | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-03-01 | — | — | US | claimed |
| CN-105012234-A | Dimethoxycurcumin polymer micelle, and preparation method and medical application thereof | UNIV YANTAI | 2015-11-04 | — | — | CN | claimed |
| US-11938233-B2 | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2024-03-26 | — | — | US | disclosed |
| US-20220054671-A1 | 1,7-DIARYL-1,6-HEPTADIENE-3,5-DIONE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2022-02-24 | — | — | US | disclosed |
| US-11191855-B2 | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2021-12-07 | — | — | US | disclosed |
| US-11117907-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | UNIVERSITY OF NORTH FLORIDA BOARD OF TRUSTEES (US) | 2021-09-14 | — | — | US | disclosed |
| US-20210087208-A1 | NOVEL CURCUMINOID-INSPIRED SYNTHETIC COMPOUNDS AS ANTI-TUMOR AGENTS | UNIVERSITY OF NORTH FLORIDA BOARD OF TRUSTEES (US) | 2021-03-25 | — | — | US | disclosed |
| US-10934241-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | UNIVERSITY OF NORTH FLORIDA BOARD OF TRUSTEES (US) | 2021-03-02 | — | — | US | disclosed |
| CN-111407749-A | Methods for treating neurodegenerative disorders | 有联生技股份有限公司 | 2020-07-14 | — | — | CN | disclosed |
| US-8841326-B2 | Therapeutic curcumin derivatives | STC.UNM (US) | 2014-09-23 | — | — | US | disclosed |
| US-8710272-B2 | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | ANDROSCIENCE CORPORATION (US) | 2014-04-29 | — | — | US | disclosed |
| US-20130338160-A1 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | Annji Pharmaceutical Co., Ltd. (TW) | 2013-12-19 | — | — | US | disclosed |
| US-20130261121-A1 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-03 | — | — | US | disclosed |
| CN-102023207-B | Method for carrying out enzyme-linked immunoadsorption detection on integral zebra fish and application thereof | PENG ENZE | 2013-06-19 | — | — | CN | disclosed |
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | disclosed |
| US-20070060644-A1 | Therapeutic curcumin derivatives | STC.UNM | 2007-03-15 | — | — | US | disclosed |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | STC.UNM | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220054671-A1 | 1,7-DIARYL-1,6-HEPTADIENE-3,5-DIONE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF | DHPS, SQLE, CYP51A1 | NFE2L2 1038/4885APP 2061/4885HSD17B10 16/4885 |
| US-20130338160-A1 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | AR, BRCA1, CYP17A1 | NFE2L2 308/4885APP 783/4885HSD17B10 213/4885 |
| US-11117907-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | FOXO3, IKZF3, FOXO1 | NFE2L2 92/4885APP 4390/4885HSD17B10 3656/4885 |
| US-20070060644-A1 | Therapeutic curcumin derivatives | FABP2, GLS2, FABP1 | NFE2L2 75/4885APP 662/4885HSD17B10 768/4885 |
| US-20210087208-A1 | NOVEL CURCUMINOID-INSPIRED SYNTHETIC COMPOUNDS AS ANTI-TUMOR AGENTS | IKZF3, FOXO3, FOXO1 | NFE2L2 68/4885APP 4495/4885HSD17B10 3478/4885 |
| US-10934241-B2 | Curcuminoid-inspired synthetic compounds as anti-tumor agents | FOXO3, FOXO1, IKZF3 | NFE2L2 204/4885APP 4358/4885HSD17B10 3614/4885 |
| US-20130261121-A1 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | AR, BRCA1, CYP17A1 | NFE2L2 308/4885APP 783/4885HSD17B10 213/4885 |
| US-11191855-B2 | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof | DHPS, SQLE, CYP51A1 | NFE2L2 1038/4885APP 2061/4885HSD17B10 16/4885 |
| US-20060276536-A1 | Cancer treatment using curcumin derivatives | BRCA1, VHL, TP53 | NFE2L2 5/4885APP 3170/4885HSD17B10 1382/4885 |
| US-11938233-B2 | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof | DHPS, SQLE, CYP51A1 | NFE2L2 1038/4885APP 2061/4885HSD17B10 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.