Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4172412 | 0.86 | GABRA1 (0.43) | TAAR1CYP1A2MAPTALDH1A1TP53 | |
| SCHEMBL459954 | 0.85 | CYP2A6 (0.43) | TAAR1CYP1A2CYP2A6MAPTTSHR | |
| SCHEMBL234202 | 0.82 | TSHR (0.39) | TAAR1TSHRALDH1A1L3MBTL1GABRA1 | |
| SCHEMBL20897139 | 0.78 | CYP2A6 (0.38) | TAAR1CYP1A2CYP2A6TSHRACHE | |
| SCHEMBL608412 | 0.78 | ESR1 (0.44) | TAAR1CYP1A2CYP2A6MAPTTSHR | |
| SCHEMBL29668555 | 0.78 | ESR1 (0.44) | TAAR1CYP1A2CYP2A6MAPTTSHR | |
| SCHEMBL52225 | 0.77 | — | — | |
| SCHEMBL9861759 | 0.76 | TAAR1 (0.43) | TAAR1CYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL3415053 | 0.76 | ESR1 (0.43) | TAAR1CYP1A2CYP2A6MAPTTSHR | |
| SCHEMBL9502847 | 0.76 | PNMT (0.38) | TAAR1CYP1A2CYP2A6MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4380554-A | Polymeric monohydroxybenzenoid hydroquinoid antioxidants | STANDARD OIL COMPANY (INDIANA) (US) | 1983-04-19 | — | — | US | claimed |
| US-4310657-A | Polymeric monohydroxybenzenoid hydroquinoid antioxidants | STANDARD OIL COMPANY (INDIANA) (US) | 1982-01-12 | — | — | US | claimed |
| US-7189864-B2 | Method of preparing intermediates useful in synthesis of retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2007-03-13 | — | — | US | disclosed |
| US-6974876-B2 | Method for preparing intermediates useful in synthesis of retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2005-12-13 | — | — | US | disclosed |
| US-20050171366-A1 | Method of preparing intermediates useful in synthesis of retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2005-08-04 | — | — | US | disclosed |
| US-20030225285-A1 | Method for preparing intermediates useful in synthesis of retroviral protease inhibitors | G.D. SEARLE & CO. | 2003-12-04 | — | — | US | disclosed |
| EP-0970066-B1 | Preparation of aminoepoxides from aminoaldehydes and an in situ formed halomethyl organometallic reagent | SEARLE & CO (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6570027-B2 | Forming a diastereoselective epoxide from a chiral alpha-amino aldehyde | G. D. SEARLE & CO. | 2003-05-27 | — | — | US | disclosed |
| US-20020161234-A1 | Method of preparing intermediates useful in synthesis of retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2002-10-31 | — | — | US | disclosed |
| US-6388094-B1 | FORMING AN AMINOEPOXIDE | G.D. SEARLE & CO. | 2002-05-14 | — | — | US | disclosed |
| EP-0855388-B1 | Method for making intermediates useful in synthesis of retroviral protease inhibitors | SEARLE & CO (US) | 2002-03-06 | — | — | EP | disclosed |
| EP-0730570-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0641333-B1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS | SEARLE & CO (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995014653-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0641333-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS. | SEARLE & CO (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023388-A1 | METHOD FOR MAKING INTERMEDIATES USEFUL IN SYNTHESIS OF RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-4380554-A | Polymeric monohydroxybenzenoid hydroquinoid antioxidants | STANDARD OIL COMPANY (INDIANA) (US) | 1983-04-19 | — | — | US | disclosed |
| US-4310657-A | Polymeric monohydroxybenzenoid hydroquinoid antioxidants | STANDARD OIL COMPANY (INDIANA) (US) | 1982-01-12 | — | — | US | disclosed |
| US-4059610-A | Process for preparing isocyanic acid derivatives | KAO SOAP CO., LTD. (JA) | 1977-11-22 | — | — | US | disclosed |
| US-4056547-A | FROM AN ALKALI METAL OR AMMONIUM CYANATE AND A BENZYL CHLORIDE, CATALYST | KAO SOAP CO., LTD. (JA) | 1977-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161234-A1 | Method of preparing intermediates useful in synthesis of retroviral protease inhibitors | PREP, DNPEP, ANPEP | TAAR1 4485/4885CYP1A2 622/4885CYP2A6 449/4885 |
| US-20030225285-A1 | Method for preparing intermediates useful in synthesis of retroviral protease inhibitors | PREP, DNPEP, ANPEP | TAAR1 4444/4885CYP1A2 656/4885CYP2A6 463/4885 |
| US-20050171366-A1 | Method of preparing intermediates useful in synthesis of retroviral protease inhibitors | PREP, DNPEP, ANPEP | TAAR1 4485/4885CYP1A2 622/4885CYP2A6 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.