Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | GSR | P00390 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599255 | 0.84 | HSP90AB1 (0.53) | HSP90AB1GAAALDH1A1GFERCYP4F2 | |
| SCHEMBL4322717 | 0.83 | TRPA1 (0.50) | HSP90AB1GSRGAACA1CA2 | |
| SCHEMBL11769359 | 0.81 | ALDH1A1 (0.62) | HSP90AB1GAAALDH1A1GFERCYP4F2 | |
| SCHEMBL17947772 | 0.80 | GABRA1 (0.50) | GSRGAACA1CA2GABRA1 | |
| SCHEMBL4323317 | 0.79 | GSR (0.53) | GSRGAACA1CA2GABRA1 | |
| SCHEMBL21891794 | 0.78 | HSP90AB1 (0.75) | HSP90AB1GAAALDH1A1GFERCYP4F2 | |
| SCHEMBL8747646 | 0.78 | GSR (0.52) | GSRGAAALDH1A1CA1CA2 | |
| SCHEMBL8204330 | 0.77 | HSP90AB1 (0.68) | HSP90AB1GAAALDH1A1GFERCYP4F2 | |
| SCHEMBL11492029 | 0.76 | GSR (0.46) | GSRGAAALDH1A1CA1CA2 | |
| SCHEMBL14485394 | 0.76 | HSP90AB1 (0.66) | HSP90AB1GAAALDH1A1GFERCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226946-B2 | Substituted phenol compounds useful for anesthesia and sedation | THERAVANCE, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-20050032753-A1 | Substituted phenol compounds useful for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2005-02-10 | — | — | US | disclosed |
| US-6815555-B2 | CONTAINING AN ESTER, ANHYDRIDE, PHOSPHONATE OR THIOESTER GROUP | THERAVANCE, INC. | 2004-11-09 | — | — | US | disclosed |
| EP-1430017-A2 | SUBSTITUTED PHENOL COMPOUNDS USEFUL FOR ANESTHESIA AND SEDATION | Theravance, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| US-20030119790-A1 | Substituted phenol compounds useful for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2003-06-26 | — | — | US | disclosed |
| WO-2003026632-A2 | SUBSTITUTED PHENOL COMPOUNDS USEFUL FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032753-A1 | Substituted phenol compounds useful for anesthesia and sedation | OPRL1, PNMT, PPARG | HSP90AB1 3325/4885GSR 1588/4885GAA 3157/4885 |
| US-20030119790-A1 | Substituted phenol compounds useful for anesthesia and sedation | OPRL1, PNMT, PPARG | HSP90AB1 3325/4885GSR 1588/4885GAA 3157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.