Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11974252 | 0.79 | ADRB2 (0.50) | TSHRLMNACYP1A2CYP3A4HPGD | |
| SCHEMBL13408054 | 0.77 | TSHR (0.47) | TSHRALOX15GABRA1GABRG2GABRB3 | |
| SCHEMBL11112611 | 0.77 | TSHR (0.47) | TSHRALOX15GABRA1GABRG2GABRB3 | |
| SCHEMBL16958544 | 0.77 | TSHR (0.39) | TSHRALOX15GABRA1GABRG2GABRB3 | |
| SCHEMBL3935095 | 0.76 | ADRB2 (0.51) | TSHRLMNACYP1A2CYP3A4HPGD | |
| SCHEMBL20355937 | 0.74 | LMNA (0.37) | LMNACYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL9271255 | 0.74 | GABRA1 (0.52) | TSHRALOX15GABRA1GABRG2GABRB3 | |
| SCHEMBL5079771 | 0.74 | SCN4A (0.47) | TSHRLMNACYP1A2CYP3A4HTR2B | |
| SCHEMBL4077369 | 0.74 | TSHR (0.45) | TSHRALOX15GABRA1GABRG2GABRB3 | |
| SCHEMBL13896644 | 0.74 | TSHR (0.45) | TSHRALOX15GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049388-B2 | Process for manufacturing an α-dihydroxy derivative and epoxy resins prepared therefrom | DOW GLOBAL TECHNOLOGIES INC. (US) | 2006-05-23 | — | — | US | claimed |
| US-6646102-B2 | Epoxidizing an alpha - halohydrin intermediate produced from a halide substitution of an alpha -dihydroxy derivative which has been obtained by a dihydroxylation reaction of an aryl allyl ether, oxidation catalysts | DOW GLOBAL TECHNOLOGIES INC. | 2003-11-11 | — | — | US | claimed |
| US-20030105268-A1 | Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom | DOW GLOBAL TECHNOLOGIES INC. | 2003-06-05 | — | — | US | claimed |
| US-7226946-B2 | Substituted phenol compounds useful for anesthesia and sedation | THERAVANCE, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-7049388-B2 | Process for manufacturing an α-dihydroxy derivative and epoxy resins prepared therefrom | DOW GLOBAL TECHNOLOGIES INC. (US) | 2006-05-23 | — | — | US | disclosed |
| EP-1406885-B1 | PROCESS FOR MANUFACTURING AN A-DIHYDROXY DERIVATIVE AND EPOXY RESINS PREPARED THEREFROM | DOW GLOBAL TECHNOLOGIES INC (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050032753-A1 | Substituted phenol compounds useful for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2005-02-10 | — | — | US | disclosed |
| US-6815555-B2 | CONTAINING AN ESTER, ANHYDRIDE, PHOSPHONATE OR THIOESTER GROUP | THERAVANCE, INC. | 2004-11-09 | — | — | US | disclosed |
| EP-1430017-A2 | SUBSTITUTED PHENOL COMPOUNDS USEFUL FOR ANESTHESIA AND SEDATION | Theravance, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1406885-A1 | PROCESS FOR MANUFACTURING AN A-DIHYDROXY DERIVATIVE AND EPOXY RESINS PREPARED THEREFROM | DOW GLOBAL TECHNOLOGIES INC. (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20040049004-A1 | Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom | THE DOW CHEMICAL COMPANY | 2004-03-11 | — | — | US | disclosed |
| US-6646102-B2 | Epoxidizing an alpha - halohydrin intermediate produced from a halide substitution of an alpha -dihydroxy derivative which has been obtained by a dihydroxylation reaction of an aryl allyl ether, oxidation catalysts | DOW GLOBAL TECHNOLOGIES INC. | 2003-11-11 | — | — | US | disclosed |
| US-20030119790-A1 | Substituted phenol compounds useful for anesthesia and sedation | THERAVANCE BIOPHARMA R&D IP, LLC | 2003-06-26 | — | — | US | disclosed |
| US-20030105268-A1 | Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom | DOW GLOBAL TECHNOLOGIES INC. | 2003-06-05 | — | — | US | disclosed |
| WO-2003026632-A2 | SUBSTITUTED PHENOL COMPOUNDS USEFUL FOR ANESTHESIA AND SEDATION | THERAVANCE, INC. (US) | 2003-04-03 | — | — | WO | disclosed |
| WO-2003004481-A1 | PROCESS FOR MANUFACTURING AN A-DIHYDROXY DERIVATIVE AND EPOXY RESINS PREPARED THEREFROM | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032753-A1 | Substituted phenol compounds useful for anesthesia and sedation | OPRL1, PNMT, PPARG | TSHR 2222/4885ALOX15 899/4885GABRA1 55/4885 |
| US-20030119790-A1 | Substituted phenol compounds useful for anesthesia and sedation | OPRL1, PNMT, PPARG | TSHR 2222/4885ALOX15 899/4885GABRA1 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.