SCHEMBL5599102

SCHEMBL5599102

CCCCn1nccc1Cc1ccc(C(Cl)OCCN(C)C)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 4/20 0.33
LMNA P02545 3/20 0.33
HRH1 P35367 3/20 0.33
CHRM2 P08172 3/20 0.33
SLC6A2 P23975 3/20 0.33
SLC6A4 P31645 3/20 0.33
SLC6A3 Q01959 3/20 0.33
ADRA2B P18089 2/20 0.33
KCNH2 Q12809 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C19 P33261 1/20 0.33
ADRA1A P35348 2/20 0.32
ADRA2A P08913 2/20 0.32
CHRM1 P11229 2/20 0.32
OPRM1 P35372 2/20 0.32
DRD3 P35462 2/20 0.32
CYP1A2 P05177 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6650020 0.95 HRH3 (0.33) HRH3HRH1CHRM2SLC6A2SLC6A4
SCHEMBL5600362 0.79 MPO (0.32) SMN1; SMN2
SCHEMBL6650639 0.77 POLB (0.39) HRH3LMNAHRH1CHRM2SLC6A2
SCHEMBL6650451 0.71 LMNA (0.39) HRH3LMNAHRH1CHRM2SLC6A2
SCHEMBL4907926 0.70 SLC6A2 (0.56) HRH3LMNAHRH1CHRM2SLC6A2
SCHEMBL6652606 0.70 P2RX7 (0.35) LMNACYP2D6CYP2C19CYP1A2TSHR
SCHEMBL6673116 0.70 HRH1 (0.54) HRH1DRD3DRD1
SCHEMBL5599428 0.68 NR1H3 (0.34) KDM4E
SCHEMBL6654163 0.68 HRH3 (0.35) HRH3LMNAHRH1CHRM2SLC6A2
SCHEMBL6650015 0.67 P2RX7 (0.36) HRH3HRH1CYP2D6CYP2C19ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1103243-B1 UTILIZATION OF ARYL(OR HETEROARYL)AZOLYLCARBINOL DERIVATIVES FOR THE TREATMENT OF TROUBLES MEDIATED BY AN EXCESS OF SUBSTANCE P ESTEVE LABOR DR (ES) 2004-01-07 EP claimed
EP-1755678-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-02-28 EP disclosed
EP-1746986-A1 ACTIVE SUBSTANCE COMBINATION COMPRISING A CARBINOL COMBINED TO AT LEAST AN NSAID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-01-31 EP disclosed
WO-2005097099-A1 ACTIVE SUBSTANCE COMBINATION COMPRISING A CARBINOL COMBINED TO AT LEAST AN NSAID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2005-10-20 WO disclosed
WO-2005097192-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2005-10-20 WO disclosed