SCHEMBL5599288

SCHEMBL5599288

CN1CCCCC1C(Cl)COc1ccc(Cc2cnn(C)c2)cc1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PSMB1 P20618 1/20 0.36
PSMB5 P28074 1/20 0.36
PSMB2 P49721 1/20 0.36
LTA4H P09960 9/20 0.36
HRH3 Q9Y5N1 1/20 0.36
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CHRNB4 P30926 3/20 0.34
CHRNA3 P32297 3/20 0.34
CHRNB2 P17787 2/20 0.34
CHRNA4 P43681 2/20 0.34
CHRNB1 P11230 1/20 0.34
CHRNB3 Q05901 1/20 0.34
SIGMAR1 Q99720 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5599107 0.97 CHRNB4 (0.37) PSMB1PSMB5PSMB2LTA4HHRH3
SCHEMBL5599117 0.89 PSMB1 (0.34) PSMB1PSMB5PSMB2LTA4HHRH3
SCHEMBL5611378 0.88 LTA4H (0.34) PSMB1PSMB5PSMB2LTA4HHRH3
SCHEMBL5599336 0.73 PSMB1 (0.45) PSMB1PSMB5PSMB2LTA4HHRH3
SCHEMBL5599111 0.73 GAA (0.38) PSMB1PSMB5PSMB2LTA4H
SCHEMBL25680303 0.65 KCNH2 (0.56) LTA4H
SCHEMBL30628842 0.64 KCNH2 (0.43)
SCHEMBL10487323 0.63 SLC6A2 (0.43) SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3
SCHEMBL6652803 0.61 CHRNB4 (0.40) HRH3SLC6A2SLC6A4SLC6A3CHRNB4
SCHEMBL16877094 0.61 CALM1 (0.48) LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1103243-B1 UTILIZATION OF ARYL(OR HETEROARYL)AZOLYLCARBINOL DERIVATIVES FOR THE TREATMENT OF TROUBLES MEDIATED BY AN EXCESS OF SUBSTANCE P ESTEVE LABOR DR (ES) 2004-01-07 EP claimed
EP-1755678-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-02-28 EP disclosed
EP-1746986-A1 ACTIVE SUBSTANCE COMBINATION COMPRISING A CARBINOL COMBINED TO AT LEAST AN NSAID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-01-31 EP disclosed
WO-2005097192-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2005-10-20 WO disclosed
WO-2005097099-A1 ACTIVE SUBSTANCE COMBINATION COMPRISING A CARBINOL COMBINED TO AT LEAST AN NSAID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2005-10-20 WO disclosed