SCHEMBL5599443

SCHEMBL5599443

Cn1ccnc1C(CO)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 2/20 0.41
FFAR1 O14842 10/20 0.41
CYP2D6 P10635 1/20 0.38
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
GAA P10253 1/20 0.37
PKM P14618 1/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37
ALOX12 P18054 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KDM2B Q8NHM5 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
KCNH2 Q12809 1/20 0.36
KMO O15229 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4902046 0.81 KDM4E (0.60) KDM4EL3MBTL1MAPTCYP2D6ALDH1A1
SCHEMBL5599337 0.78 KDM4E (0.49) KDM4EL3MBTL1MAPTFFAR1CYP2D6
SCHEMBL5599568 0.76 KDM4E (0.50) KDM4EL3MBTL1MAPTFFAR1CYP2D6
SCHEMBL5600881 0.76 FFAR1 (0.53) KDM4EL3MBTL1MAPTFFAR1CYP2D6
SCHEMBL5599142 0.75 FFAR1 (0.52) KDM4EL3MBTL1MAPTFFAR1CYP2D6
SCHEMBL5599264 0.71 KDM4E (0.41) KDM4EL3MBTL1MAPTFFAR1ALDH1A1
SCHEMBL4911105 0.71 SLC6A4 (0.45) KDM4EL3MBTL1MAPTCYP2D6ALDH1A1
SCHEMBL4899031 0.70 L3MBTL1 (0.39) KDM4EL3MBTL1MAPTFFAR1CYP2D6
Bromide SCHEMBL28342680 0.69 L3MBTL1 (0.43) KDM4EL3MBTL1MAPTFFAR1ALDH1A1
SCHEMBL4911118 0.69 KMT2A (0.44) KDM4EL3MBTL1MAPTCYP2D6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1103243-B1 UTILIZATION OF ARYL(OR HETEROARYL)AZOLYLCARBINOL DERIVATIVES FOR THE TREATMENT OF TROUBLES MEDIATED BY AN EXCESS OF SUBSTANCE P ESTEVE LABOR DR (ES) 2004-01-07 EP claimed
EP-1755678-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2007-02-28 EP disclosed
WO-2005097192-A2 ACTIVE SUBSTANCE COMBINATION OF A CARBINOL COMPOUND AND AN OPIOID LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2005-10-20 WO disclosed