Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599571 | 0.96 | PTGDR2 (0.37) | DRD2PTGDR2GNRHRKCNH2P2RX7 | |
| SCHEMBL5780226 | 0.93 | CDYL (0.35) | DRD2PTGDR2GNRHRKCNH2ALDH1A1 | |
| SCHEMBL5599828 | 0.90 | CHRM1 (0.38) | DRD2GNRHRKCNH2MGLLCHRM1 | |
| SCHEMBL5599289 | 0.85 | DRD2 (0.37) | DRD2PTGDR2GNRHRKCNH2P2RX7 | |
| SCHEMBL5600563 | 0.85 | TSHR (0.36) | DRD2PTGDR2P2RX7CHRM1CHRM3 | |
| SCHEMBL5780173 | 0.84 | DRD2 (0.36) | DRD2PTGDR2GNRHRKCNH2P2RX7 | |
| SCHEMBL5783150 | 0.82 | PTGDR2 (0.36) | DRD2PTGDR2P2RX7CHRM1CHRM3 | |
| SCHEMBL5779582 | 0.82 | P2RX7 (0.41) | DRD2PTGDR2GNRHRKCNH2P2RX7 | |
| SCHEMBL5782575 | 0.82 | GPR183 (0.34) | DRD2PTGDR2P2RX7CHRM1CHRM3 | |
| SCHEMBL5599553 | 0.81 | PTGDR2 (0.33) | DRD2PTGDR2GNRHRKCNH2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |