Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | GNRHR | P30968 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779253 | 0.91 | CHRM1 (0.38) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5600563 | 0.86 | TSHR (0.36) | P2RX7PTGDR2CHRM1CHRM3DRD2 | |
| SCHEMBL5599106 | 0.86 | CHRM1 (0.40) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5599289 | 0.83 | DRD2 (0.37) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5782575 | 0.83 | GPR183 (0.34) | P2RX7PTGDR2CHRM1CHRM3DRD2 | |
| SCHEMBL5599763 | 0.82 | DRD2 (0.38) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5599553 | 0.82 | PTGDR2 (0.33) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5780173 | 0.82 | DRD2 (0.36) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5599571 | 0.82 | PTGDR2 (0.37) | P2RX7PTGDR2KCNH2GNRHRCHRM1 | |
| SCHEMBL5783150 | 0.80 | PTGDR2 (0.36) | P2RX7PTGDR2CHRM1CHRM3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |