Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5603293 | 0.95 | POLB (0.32) | POLBDRD2SLC6A4MKNK2MKNK1 | |
| Hydrochloric Acid SCHEMBL5601451 | 0.88 | POLB (0.34) | POLBMKNK2MKNK1HTTFGFR1 | |
| Hydrochloric Acid SCHEMBL5602330 | 0.85 | HTT (0.34) | POLBMKNK2MKNK1HTTMAPT | |
| Hydrochloric Acid SCHEMBL5602366 | 0.83 | JUN (0.31) | DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5600211 | 0.82 | — | — | |
| Fluoride Ion SCHEMBL5603710 | 0.81 | DRD2 (0.30) | DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5599607 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5602770 | 0.80 | CYP11B2 (0.33) | — | |
| Hydrochloric Acid SCHEMBL5603446 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5603189 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |