Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959196 | 0.85 | HDAC4 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1609729 | 0.82 | HDAC3 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10625651 | 0.81 | SYK (0.43) | NPC1RAB9ASMN1; SMN2PPARGPPARA | |
| SCHEMBL29044862 | 0.79 | PPARG (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27349791 | 0.76 | POLB (0.50) | NPC1RAB9ASMN1; SMN2KLK5KDM4E | |
| SCHEMBL10626852 | 0.75 | SYK (0.44) | NPC1RAB9ASMN1; SMN2CTSSCTSL | |
| SCHEMBL12604847 | 0.75 | HDAC3 (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27349789 | 0.75 | APAF1 (0.57) | RAB9ASMN1; SMN2ALDH1A1PPARGPPARA | |
| SCHEMBL1609731 | 0.75 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13855987 | 0.75 | BRD4 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311281-B1 | ANTIMICROBIAL SULFONAMIDE DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS | MIGENIX INC (CA) | 2007-10-24 | — | — | EP | disclosed |
| US-6750199-B2 | SULFONYLATION CORE ANTIBIOTIC | MICROLOGIX BIOTECH INC. (CA) | 2004-06-15 | — | — | US | disclosed |
| US-20020028771-A1 | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics | BIOSOURCE PHARM, INC. | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028771-A1 | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics | STS, CUTA, LSS | HDAC3 3490/4885HDAC4 2625/4885HDAC1 2634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.