Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593366 | 0.82 | KMT2A (0.42) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL5593372 | 0.82 | KMT2A (0.42) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL5593028 | 0.78 | GAA (0.48) | SMN1; SMN2CYP1A2ALDH1A1HPGDCYP2D6 | |
| SCHEMBL6401623 | 0.75 | NOTUM (0.61) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL5604308 | 0.74 | BRAF (0.34) | SMN1; SMN2CYP1A2ALDH1A1HPGDCYP2D6 | |
| SCHEMBL5593360 | 0.72 | TSHR (0.55) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL4204403 | 0.72 | EPHX2 (0.57) | POLBSMN1; SMN2CYP1A2ALDH1A1EPHX2 | |
| SCHEMBL3863217 | 0.72 | KDM4A (0.43) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL5602271 | 0.71 | HTT (0.43) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 | |
| SCHEMBL11495864 | 0.71 | POLB (0.78) | POLBSMN1; SMN2CYP1A2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |