SCHEMBL5604776

SCHEMBL5604776

Cc1ccc(O[Si](Cl)(Cl)Oc2ccc(C)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.48
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44
TDP1 Q9NUW8 2/20 0.42
CYP3A4 P08684 1/20 0.41
TSHR P16473 1/20 0.41
TEAD4 Q15561 1/20 0.41
LMNA P02545 2/20 0.39
ALDH1A1 P00352 2/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
RELA Q04206 1/20 0.38
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
GAA P10253 1/20 0.36
CYP2C9 P11712 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5027470 0.84 ACHE (0.48) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL1039748 0.78 ACHE (0.52) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL3873409 0.76 ACHE (0.50) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL3871449 0.76 ACHE (0.50) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL2016960 0.76 ACHE (0.50) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL9331846 0.74 ACHE (0.48) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL7859078 0.74 ACHE (0.48) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL9705011 0.74 ACHE (0.48) ACHEKMT2AMEN1TDP1CYP3A4
SCHEMBL1042948 0.72 LTA4H (0.45) KMT2AMEN1TSHRALDH1A1MAPT
SCHEMBL10574326 0.72 ACHE (0.52) ACHEKMT2AMEN1TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0447066-B2 Pneumatic tyres BRIDGESTONE CORP (JP) 2000-08-16 EP claimed
US-5409969-A Comprising silica filler, carbon black, silane coupler, living polymer of butadiene-styrene BRIDGESTONE CORPORATION (JP) 1995-04-25 US claimed
EP-0447066-A1 Pneumatic tyres Bridgestone Corporation (JP) 1991-09-18 EP claimed
US-20070208126-A1 Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires PIRELLI PNEUMATICI S.P.A. 2007-09-06 US disclosed
US-20040220324-A1 First modified conjugated diolefin-vinylaromatic copolymer; second conjugated diolefin-vinylaromatic copolymer; first carbon black-based reinforcing filler; second silica-based reinforcing filler PIRELLI PNEUMATICI S.P.A. 2004-11-04 US disclosed
EP-0972790-B1 Process for producing a vulcanizable rubber composition including carbon black-based and silicia-based reinforcing fillers PIRELLI (IT) 2004-09-22 EP disclosed
EP-1189767-B1 LOW ROLLING RESISTANCE TIRE FOR VEHICLES PIRELLI (IT) 2004-07-28 EP disclosed
EP-0934973-B1 Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires PIRELLI PNEUMATICIS P A (IT) 2004-04-28 EP disclosed
US-6624233-B2 Mechanical properties PIRELLI PNEUMATICI S.P.A. (IT) 2003-09-23 US disclosed
US-20020143096-A1 Low rolling resistance tire for vehicles PIRELLI PNEUMATICI S.P.A. (IT) 2002-10-03 US disclosed
US-20020107317-A1 VULCANIZABLE RUBBER COMPOSITION, IN PARTICULAR FOR LOW ROLLING RESISTANCE TREADS OF VEHICLE TIRES PIRELLI PNEUMATICI S.P.A (IT) 2002-08-08 US disclosed
EP-0447066-B2 Pneumatic tyres BRIDGESTONE CORP (JP) 2000-08-16 EP disclosed
EP-0972790-A1 Process for producing a vulcanizable rubber composition including carbon black-based and silicia-based reinforcing fillers PIRELLI PNEUMATICI Società per Azioni (IT) 2000-01-19 EP disclosed
EP-0934973-A1 Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires PIRELLI PNEUMATICI S.p.A. (IT) 1999-08-11 EP disclosed
US-5496883-A COMPRISING TREAD RUBBER OF POLYBUTADIENE POLYMER OR COPOLYMER CONTAINING SILICA AND MODIFIED WITH SILANE COUPLING AGENT; COUPLING AGENT; WET SKID RESISTANCE, LOW ROLLLING RESISTANCE BRIDGESTONE CORPORATION (JP) 1996-03-05 US disclosed
US-5409969-A Comprising silica filler, carbon black, silane coupler, living polymer of butadiene-styrene BRIDGESTONE CORPORATION (JP) 1995-04-25 US disclosed
EP-0299074-B1 TIRE Bridgestone Corporation (JP) 1992-01-29 EP disclosed
US-5066721-A TIRES MADE OF SILICA FILLED, SILANE MODIFIED RUBBER BRIDGESTONE CORPORATION (JP) 1991-11-19 US disclosed
EP-0447066-A1 Pneumatic tyres Bridgestone Corporation (JP) 1991-09-18 EP disclosed
EP-0299074-A1 TIRE Bridgestone Corporation (JP) 1989-01-18 EP disclosed