Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763549 | 0.88 | CA1 (0.39) | ACHEKMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL17245006 | 0.85 | TSHR (0.43) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL3871449 | 0.83 | ACHE (0.50) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL3873409 | 0.83 | ACHE (0.50) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL19601195 | 0.83 | GAA (0.61) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL9171797 | 0.83 | MMP13 (0.37) | ACHEKMT2AMEN1TDP1NPC1 | |
| SCHEMBL15220292 | 0.80 | ACHE (0.42) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL1039748 | 0.80 | ACHE (0.52) | ACHEKMT2AMEN1TDP1CYP3A4 | |
| SCHEMBL17881929 | 0.80 | ESR2 (0.39) | KMT2ATDP1CYP3A4NPC1RAB9A | |
| SCHEMBL9714337 | 0.80 | ESR2 (0.39) | KMT2ATDP1CYP3A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1760078-A1 | Substituted pyrazoline compounds; methods for their preparation | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-03-07 | — | — | EP | claimed |
| WO-2007009710-A2 | SUBSTITUTED PYRAZOLINE COMPOUNDS: METHODS FOR THEIR PREPARATION | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-01-25 | — | — | WO | claimed |
| US-7129311-B2 | Additives to prevent degradation of alkyl-hydrogen siloxanes | ARCH SPECIALTY CHEMICALS, INC. (US) | 2006-10-31 | — | — | US | claimed |
| US-20060159861-A1 | Additives to prevent degradation of alkyl-hydrogen siloxanes | ARCH SPECIALTY CHEMICALS, INC. (US) | 2006-07-20 | — | — | US | claimed |
| EP-1573086-A2 | ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES | Arch Specialty Chemicals, Inc. (US) | 2005-09-14 | — | — | EP | claimed |
| US-20040127070-A1 | Additives to prevent degradation of alkyl-hydrogen siloxanes | ARCH SPECIALTY CHEMICALS, INC. | 2004-07-01 | — | — | US | claimed |
| WO-2004027110-A2 | ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES | ARCH SPECIALTY CHEMICALS, INC. (US) | 2004-04-01 | — | — | WO | claimed |
| US-11912731-B2 | Use of silylated formiates as hydrosilane equivalents | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2024-02-27 | — | — | US | disclosed |
| US-20180094003-A1 | FLAME RETARDANT FILLER | INTERNATIONAL BUSINESS MACHINES CORPORATION | 2018-04-05 | — | — | US | disclosed |
| US-8207156-B2 | Substituted pyrazoline compounds, their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-26 | — | — | US | disclosed |
| US-20110160181-A1 | SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-06-30 | — | — | US | disclosed |
| US-7959990-B2 | Adjustment of liquid crystals; oligomers, dendrimers, or polymer in solution is applied to support; crosslinking by radiation or polarized light | ROLIC AG (CH) | 2011-06-14 | — | — | US | disclosed |
| US-7897589-B2 | Substituted pyrazoline compounds, their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-03-01 | — | — | US | disclosed |
| US-20060270787-A1 | Additives to prevent degradation of alkyl-hydrogen siloxanes | VERSUM MATERIALS US, LLC | 2006-11-30 | — | — | US | disclosed |
| US-7129311-B2 | Additives to prevent degradation of alkyl-hydrogen siloxanes | ARCH SPECIALTY CHEMICALS, INC. (US) | 2006-10-31 | — | — | US | disclosed |
| US-20060159861-A1 | Additives to prevent degradation of alkyl-hydrogen siloxanes | ARCH SPECIALTY CHEMICALS, INC. (US) | 2006-07-20 | — | — | US | disclosed |
| EP-1573086-A2 | ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES | Arch Specialty Chemicals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040127070-A1 | Additives to prevent degradation of alkyl-hydrogen siloxanes | ARCH SPECIALTY CHEMICALS, INC. | 2004-07-01 | — | — | US | disclosed |
| WO-2004027110-A2 | ADDITIVES TO PREVENT DEGRADATION OF ALKYL-HYDROGEN SILOXANES | ARCH SPECIALTY CHEMICALS, INC. (US) | 2004-04-01 | — | — | WO | disclosed |
| US-4642363-A | Method of preparing trialkyl organo-oxysilanes | DYNAMIT NOBEL AG (DE) | 1987-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180094003-A1 | FLAME RETARDANT FILLER | PCBP1, LRBA, BICRA | ACHE 432/4885KMT2A 1032/4885MEN1 3635/4885 |
| US-11912731-B2 | Use of silylated formiates as hydrosilane equivalents | PFAS, EPM2A, CYP2F1 | ACHE 5/4885KMT2A 1150/4885MEN1 529/4885 |
| US-20110160181-A1 | SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS | PIR, SYMPK, P2RX5 | ACHE 499/4885KMT2A 2846/4885MEN1 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.