Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | UGCG | Q16739 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606615 | 1.00 | ROCK2 (0.40) | ROCK2KMT2AMEN1ALDH1A1USP2 | |
| SCHEMBL1737729 | 1.00 | ROCK2 (0.40) | ROCK2KMT2AMEN1ALDH1A1USP2 | |
| SCHEMBL1737717 | 0.90 | ROCK2 (0.41) | ROCK2KMT2AALDH1A1USP2LMNA | |
| SCHEMBL1737760 | 0.90 | ROCK2 (0.41) | ROCK2KMT2AALDH1A1USP2LMNA | |
| SCHEMBL1737713 | 0.90 | ROCK2 (0.41) | ROCK2KMT2AALDH1A1USP2LMNA | |
| SCHEMBL1738324 | 0.87 | HTR1A (0.46) | ROCK2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1737867 | 0.87 | NCF1 (0.45) | ROCK2KMT2AALDH1A1USP2LMNA | |
| SCHEMBL1740165 | 0.84 | FPR2 (0.43) | ROCK2KMT2ALMNAHTR1ASLC6A2 | |
| SCHEMBL1738321 | 0.84 | FPR2 (0.43) | ROCK2KMT2ALMNAHTR1ASLC6A2 | |
| SCHEMBL5606335 | 0.84 | ROCK2 (0.40) | ROCK2CASP1CASP7UGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |