Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 1/20 | 0.36 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558213 | 0.96 | MAPT (0.40) | SLC6A2SLC6A4MAPTHTTKDM4E | |
| SCHEMBL6254049 | 0.84 | LMNA (0.39) | SLC6A2SLC6A4MAPTHTTALDH1A1 | |
| SCHEMBL5598374 | 0.83 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3HIF1ACYP2D6 | |
| SCHEMBL22411187 | 0.83 | SIGMAR1 (0.39) | SLC6A2SLC6A4DRD2DRD3SLC6A3 | |
| SCHEMBL5160797 | 0.80 | SLC6A2 (0.47) | SLC6A2SLC6A4MAPTALDH1A1LMNA | |
| SCHEMBL5160805 | 0.80 | SLC6A2 (0.47) | SLC6A2SLC6A4MAPTALDH1A1LMNA | |
| SCHEMBL6252738 | 0.78 | MAPT (0.40) | SLC6A2SLC6A4MAPTHTTKDM4E | |
| Hydrochloric Acid SCHEMBL27536771 | 0.78 | DRD2 (0.41) | MEN1KMT2ADRD2DRD3CYP2D6 | |
| SCHEMBL5160139 | 0.78 | MEN1 (0.38) | SLC6A2SLC6A4MAPTHTTKDM4E | |
| Elzasonan SCHEMBL5159647 | 0.75 | SLC6A2 (0.49) | SLC6A2SLC6A4MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2005053701-A1 | COMBINATION OF DOPAMINE AGONISTS AND ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES | PFIZER PRODUCTS INC. (US) | 2005-06-16 | — | — | WO | claimed |