Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794551 | 0.82 | ALDH1A1 (0.42) | GSRALDH1A1PKMDPP9DPP8 | |
| SCHEMBL5705701 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1PKMMCL1 | |
| SCHEMBL195776 | 0.80 | ALDH1A1 (0.43) | GSRALDH1A1PKMDPP9DPP8 | |
| SCHEMBL542270 | 0.79 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1PKMMCL1 | |
| SCHEMBL1696964 | 0.78 | ALDH1A1 (0.46) | GSRALDH1A1PKMDPP9DPP8 | |
| Lysine SCHEMBL9752090 | 0.76 | GSR (0.67) | GSRTHRBDPP9DPP8DPP7 | |
| SCHEMBL15623808 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2SLC7A5ALDH1A1PKMMCL1 | |
| SCHEMBL28490356 | 0.74 | ALDH1A1 (0.49) | GSRALDH1A1PKMDPP9DPP8 | |
| SCHEMBL1696971 | 0.74 | ALDH1A1 (0.49) | GSRALDH1A1PKMDPP9DPP8 | |
| Lysine SCHEMBL1258691 | 0.74 | GSR (0.74) | GSRTHRBSLC7A5NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828281-A2 | POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2005118681-A2 | POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME | ADVANCED CARDIOVASCULAR SYSTEMS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |