Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | TDO2 | P48775 | 2/20 | 0.48 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31419814 | 0.87 | ALDH1A1 (0.56) | APAF1IDO1TDO2IDO2MEN1 | |
| SCHEMBL10552036 | 0.84 | NPC1 (0.58) | MEN1KMT2ANPC1HSP90AA1RAB9A | |
| SCHEMBL30103255 | 0.84 | NPC1 (0.58) | MEN1KMT2ANPC1HSP90AA1RAB9A | |
| SCHEMBL9953129 | 0.82 | POLB (0.41) | IDO1TDO2IDO2POLBPIK3CD | |
| SCHEMBL15815616 | 0.80 | PIK3CD (0.57) | APAF1IDO1TDO2IDO2MEN1 | |
| SCHEMBL15815615 | 0.80 | PIK3CD (0.57) | APAF1IDO1TDO2IDO2MEN1 | |
| SCHEMBL23045340 | 0.79 | TDO2 (0.54) | IDO1TDO2IDO2POLB | |
| SCHEMBL29623384 | 0.79 | TDO2 (0.54) | IDO1TDO2IDO2POLB | |
| SCHEMBL28367595 | 0.78 | SMN1; SMN2 (0.66) | MEN1KMT2ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL15819241 | 0.77 | PDE10A (0.53) | MEN1KMT2ANPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |