Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.39 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954657 | 0.88 | HPD (0.44) | POLBTDO2IDO2IDO1HCAR1 | |
| SCHEMBL9954457 | 0.85 | HCAR1 (0.50) | ESR2CA12CA1CA2CA9 | |
| SCHEMBL9953965 | 0.84 | POLB (0.41) | POLBESR2CA12CA1CA2 | |
| SCHEMBL9954423 | 0.84 | POLB (0.41) | POLBTDO2IDO2IDO1PIK3CD | |
| SCHEMBL10517573 | 0.83 | NPC1 (0.46) | POLBESR2 | |
| SCHEMBL5607040 | 0.82 | APAF1 (0.48) | POLBTDO2IDO2IDO1PIK3CD | |
| SCHEMBL9954122 | 0.81 | ESR2 (0.44) | POLBESR2CA12CA1CA2 | |
| SCHEMBL9955025 | 0.81 | ESR2 (0.41) | POLBESR2CA12CA1CA2 | |
| SCHEMBL9954576 | 0.81 | ESR2 (0.41) | POLBESR2CA12CA1CA2 | |
| SCHEMBL9953879 | 0.81 | GLA (0.51) | POLBTDO2IDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |