Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | MMP7 | P09237 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3488060 | 0.76 | PIM1 (0.39) | PIM1PIM2KDM4EALDH1A1LMNA | |
| SCHEMBL5606136 | 0.63 | SMN1; SMN2 (0.43) | PIM1PIM2KDM4EALDH1A1LMNA | |
| SCHEMBL5607313 | 0.63 | SMN1; SMN2 (0.38) | KDM4EALDH1A1LMNAGLAGAA | |
| SCHEMBL27085593 | 0.61 | MAOB (0.61) | KDM4EALDH1A1SMN1; SMN2CA12CA9 | |
| SCHEMBL29546494 | 0.61 | PIM1 (0.56) | PIM1PIM2KDM4EALDH1A1LMNA | |
| SCHEMBL3487918 | 0.60 | SMN1; SMN2 (0.38) | KDM4EALDH1A1LMNAGLAGAA | |
| SCHEMBL9263927 | 0.59 | LMNA (0.63) | PIM1PIM2KDM4EALDH1A1LMNA | |
| SCHEMBL16984446 | 0.59 | ALDH1A1 (0.51) | KDM4EALDH1A1LMNAGLAGAA | |
| SCHEMBL17161458 | 0.58 | PIM1 (0.68) | PIM1PIM2KDM4EALDH1A1LMNA | |
| SCHEMBL17179765 | 0.58 | PIM1 (0.68) | PIM1PIM2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |