Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | GALR2 | O43603 | 1/20 | 0.34 |
| ▸ | BMI1 | P35226 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5614183 | 0.89 | P2RX3 (0.37) | ALDH1A1KMT2ANPSR1P2RX3 | |
| SCHEMBL17844142 | 0.86 | GAA (0.38) | MAPTALDH1A1NPSR1LMNAFAAH | |
| SCHEMBL5606522 | 0.86 | PLK1 (0.41) | MAPTMEN1ALDH1A1KMT2AADAMTS5 | |
| SCHEMBL5606992 | 0.84 | P2RX3 (0.41) | MAPTMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL5606915 | 0.84 | ALDH1A1 (0.43) | MAPTMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL5606238 | 0.81 | PGR (0.38) | MAPTMEN1ALDH1A1KMT2ANPSR1 | |
| SCHEMBL5613996 | 0.77 | MAPT (0.46) | MAPTMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL5607329 | 0.77 | NPC1 (0.41) | MEN1ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL5613790 | 0.76 | P2RX3 (0.35) | MAPTMEN1ALDH1A1KMT2ATEAD4 | |
| SCHEMBL17844161 | 0.75 | FAAH (0.44) | MAPTMEN1ALDH1A1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | claimed |