Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR known ✓ | P25105 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4460689 | 0.88 | BRD4 (0.34) | KIF11BRD4CREBBPP4HB | |
| Hydrochloric Acid SCHEMBL6514429 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL6324026 | 0.84 | PDCD1 (0.34) | BRD4 | |
| Hydrochloric Acid SCHEMBL5607325 | 0.83 | BRD4 (0.32) | KIF11BRD4CREBBPPTAFR | |
| Hydrochloric Acid SCHEMBL31255983 | 0.82 | KIF11 (0.34) | KIF11BRD4CREBBPTSHRNPC1 | |
| Hydrochloric Acid SCHEMBL29612278 | 0.82 | KIF11 (0.34) | KIF11BRD4CREBBPTSHRNPC1 | |
| Hydrochloric Acid SCHEMBL7203230 | 0.82 | KIF11 (0.34) | KIF11BRD4CREBBPTSHRNPC1 | |
| Hydrochloric Acid SCHEMBL5606398 | 0.81 | KIF11 (0.33) | KIF11BRD4CREBBPTSHRNPC1 | |
| Hydrochloric Acid SCHEMBL2523909 | 0.81 | KIF11 (0.33) | KIF11BRD4CREBBPTSHRNPC1 | |
| Hydrochloric Acid SCHEMBL28418788 | 0.81 | KIF11 (0.33) | KIF11BRD4CREBBPTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771484-A1 | METHOD FOR PRODUCING ULTRAHIGH MOLECULAR WEIGHT POLYMERS WHILE USING UNBRIDGED METALLOCENE CATALYSTS | Ticona GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006008127-A1 | METHOD FOR PRODUCING ULTRAHIGH MOLECULAR WEIGHT POLYMERS WHILE USING UNBRIDGED METALLOCENE CATALYSTS | TICONA GMBH (DE) | 2006-01-26 | — | — | WO | disclosed |