Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.68 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.68 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29683776 | 1.00 | CYP11B2 (0.68) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL5607529 | 0.85 | CYP11B2 (0.57) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL10402898 | 0.84 | CYP11B1 (0.56) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL11466575 | 0.84 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL11209313 | 0.84 | CYP11B1 (0.56) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL2627023 | 0.82 | CYP11B2 (0.54) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL31608568 | 0.82 | CYP11B2 (0.65) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL319265 | 0.82 | CYP11B2 (0.65) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 | |
| SCHEMBL4508891 | 0.82 | CYP11B2 (1.00) | CYP11B2CYP11B1CYP19A1NISCH | |
| SCHEMBL31666281 | 0.80 | CYP11B2 (0.62) | CYP11B2CYP11B1CYP19A1NISCHPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230084690-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2023-03-16 | — | — | US | disclosed |
| CN-114656452-A | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders | 阿尔维纳斯运营股份有限公司 | 2022-06-24 | — | — | CN | disclosed |
| EP-3956334-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | Merck Patent GmbH (DE) | 2022-02-23 | — | — | EP | disclosed |
| CN-113692407-A | Compounds for optically active devices | 默克专利股份有限公司 | 2021-11-23 | — | — | CN | disclosed |
| WO-2020212543-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2020-10-22 | — | — | WO | disclosed |
| EP-1754709-A1 | Process for preparing vinylphosphates | DSM IP Assets B.V. (NL) | 2007-02-21 | — | — | EP | disclosed |
| EP-1509484-A2 | PROCESS FOR PREPARING VINYLAROMATIC COMPOUNDS | DSM IP Assets B.V. (NL) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003102202-A2 | PROCESS FOR PREPARING VINYLAROMATIC COMPOUNDS | DSM IP ASSETS B.V. (NL) | 2003-12-11 | — | — | WO | disclosed |
| US-6608212-B1 | Palladium catalyzed coupling of a vinylphosphate and aryl-metal halide; preparation of such as 1-(4-(2-(pyrrolidin-n-yl)-ethoxy)phenyl)-6-methoxy-3,4-dihydronaphthalene | PFIZER, INC. | 2003-08-19 | — | — | US | disclosed |
| US-4048330-A | Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia | SYNTEX CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |
| US-4009197-A | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof | SYNTEX CORPORATION (PM) | 1977-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230084690-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | PDE6C, UACA, PDE6A | CYP11B2 3488/4885CYP11B1 3581/4885CYP19A1 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.