Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604080 | 0.79 | TDP1 (0.57) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6834849 | 0.75 | GAA (0.47) | MAPTALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL6604083 | 0.72 | MAPT (0.53) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6834770 | 0.71 | CHRNA7 (0.49) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL772266 | 0.69 | LCK (0.60) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL4194371 | 0.67 | SCD (0.59) | HPGDCHRM4NPC1 | |
| SCHEMBL14954845 | 0.67 | CHRM4 (0.81) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL14148663 | 0.66 | LMNA (0.58) | MAPTALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL432169 | 0.65 | CHRM4 (1.00) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL12124189 | 0.65 | ALDH1A1 (0.58) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |