Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604080 | 0.78 | TDP1 (0.57) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL772266 | 0.74 | LCK (0.60) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL27562376 | 0.72 | RAB9A (0.64) | MAPTALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL5608032 | 0.72 | MAPT (0.48) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL6603764 | 0.72 | LCK (0.56) | — | |
| SCHEMBL6606810 | 0.70 | LCK (0.57) | MAPTALDH1A1LMNAKMT2AHTT | |
| SCHEMBL15222680 | 0.70 | CHRM4 (0.67) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL432169 | 0.69 | CHRM4 (1.00) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL12124189 | 0.69 | ALDH1A1 (0.58) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL14954845 | 0.68 | CHRM4 (0.81) | MAPTALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169038-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | claimed |
| EP-1169038-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000062778-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-26 | — | — | WO | claimed |