Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 7/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.31 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | PTGFR | P43088 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755485 | 0.83 | HRH4 (0.37) | MAOAMAOBALPLKDRHRH4 | |
| SCHEMBL6445833 | 0.83 | EPAS1 (0.34) | ALPLEPHX2 | |
| SCHEMBL27643695 | 0.81 | MAOA (0.35) | MAOAMAOBALPLKDRHRH4 | |
| SCHEMBL5608059 | 0.79 | KCNK3 (0.38) | MAOAMAOBALDH1A1L3MBTL1SLC6A4 | |
| SCHEMBL3641536 | 0.79 | HTT (0.40) | ALDH1A1 | |
| SCHEMBL16956764 | 0.76 | MAOA (0.35) | MAOAMAOBALPLKDRHRH4 | |
| SCHEMBL16952339 | 0.74 | HRH4 (0.39) | MAOAMAOBALPLKDRHRH4 | |
| SCHEMBL20303638 | 0.74 | HRH4 (0.39) | MAOAMAOBALPLKDRHRH4 | |
| SCHEMBL6604767 | 0.74 | HRH4 (0.39) | MAOAMAOBALPLHRH4SLC6A4 | |
| SCHEMBL408055 | 0.73 | PTGDR2 (0.51) | MAOAMAOBALPLKDREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583742-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060870-A1 | NOVEL CB 1 RECEPTOUR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |