Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278966 | 0.89 | ACHE (0.50) | TSHRKMT2ASMN1; SMN2ACHEGAA | |
| SCHEMBL8737305 | 0.87 | HTR1A (0.55) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9486403 | 0.86 | MAPT (0.43) | TSHRKMT2AARACHE | |
| SCHEMBL11419709 | 0.84 | AR (0.55) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11428438 | 0.84 | AR (0.64) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL5545759 | 0.84 | TSHR (0.43) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL10513719 | 0.84 | TSHR (0.44) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL15347792 | 0.84 | TSHR (0.43) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL29637724 | 0.83 | TSHR (0.65) | TSHRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL127000 | 0.83 | TSHR (0.65) | TSHRKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354887-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1097158-B1 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20050054882-A1 | Diaryl ether condensation reactions | NSF - DEITR | 2005-03-10 | — | — | US | disclosed |
| US-6762329-B2 | EFFECTS OF ACIDIC ACTIVATORS ON ULLMANN-TYPE COUPLINGS INVOLVING ELECTRON-POOR AND/OR RELATIVELY INSOLUBLE SUBSTRATES. | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2004-07-13 | — | — | US | disclosed |
| EP-1354887-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | Massachusetts Insitute of Technology (US) | 2003-10-22 | — | — | EP | disclosed |
| US-20030088128-A1 | Diaryl ether condensation reactions | NATIONAL SCIENCE FOUNDATION | 2003-05-08 | — | — | US | disclosed |
| US-6395939-B1 | CATALYTIC ETHERIFICATION AND CONDENSATION WITH COPPER CATALYSTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-05-28 | — | — | US | disclosed |
| EP-1097158-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002887-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-01-20 | — | — | WO | disclosed |
| WO-1999018057-A1 | PREPARATION OF DIARYL ETHER BY CONDENSATION REACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-04-15 | — | — | WO | disclosed |
| US-5250657-A | Process for preparing polyarylene thioether | SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) | 1993-10-05 | — | — | US | disclosed |
| EP-0440106-A2 | Process for preparing polyarylene thioethers | SEISAN KAIHATSU KAGAKU KENKYUSHO (JP) | 1991-08-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054882-A1 | Diaryl ether condensation reactions | NSFL1C, DERL1, UBE2M | TSHR 4862/4885KMT2A 1576/4885MEN1 2565/4885 |
| US-20030088128-A1 | Diaryl ether condensation reactions | NSFL1C, DERL1, UBE2M | TSHR 4862/4885KMT2A 1576/4885MEN1 2565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.