Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963648 | 0.86 | PDE2A (0.51) | IDO1TDO2PDE2AGSK3BGAA | |
| SCHEMBL20551557 | 0.86 | PDE2A (0.51) | IDO1TDO2PDE2AGSK3BGAA | |
| SCHEMBL6446889 | 0.83 | CES2 (0.43) | IDO1TDO2PDE2AGSK3BCES2 | |
| SCHEMBL6448282 | 0.81 | PDE2A (0.36) | PDE2AMEN1KMT2AGSK3BCES2 | |
| SCHEMBL3248499 | 0.81 | PDE2A (0.42) | PDE2AMEN1TSHRKMT2AGSK3B | |
| SCHEMBL27551257 | 0.79 | PDE2A (0.47) | IDO1TDO2PDE2AMEN1TSHR | |
| SCHEMBL27490326 | 0.79 | IDO1 (0.40) | IDO1TDO2PDE2AMEN1TSHR | |
| SCHEMBL6442608 | 0.78 | CES2 (0.43) | CES2 | |
| SCHEMBL20551270 | 0.78 | CES2 (0.43) | CES2 | |
| SCHEMBL17604466 | 0.77 | DGAT1 (0.35) | KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-A1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005108393-A1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-17 | — | — | WO | disclosed |