Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19692916 | 0.79 | KDM4E (0.39) | KDM4EKMT2APDCD1CD274HPGD | |
| SCHEMBL3145870 | 0.76 | MTNR1A (0.45) | KDM4EKMT2APDCD1CD274HPGD | |
| SCHEMBL12462407 | 0.76 | SETDB1 (0.49) | PTGS2GRIA4POLBKDM4ETSHR | |
| SCHEMBL19693021 | 0.75 | HRH1 (0.43) | KDM4EPDCD1CD274LMNA | |
| SCHEMBL1774729 | 0.73 | DPP4 (0.36) | PTGS2KMT2APDCD1CD274HPGD | |
| SCHEMBL21408573 | 0.73 | KEAP1 (0.44) | PTGS2KDM4EHPGDCA12CA2 | |
| SCHEMBL5611030 | 0.72 | SETDB1 (0.40) | PTGS2GRIA4POLBKDM4ETSHR | |
| SCHEMBL5796914 | 0.71 | ALDH1A1 (0.41) | TSHRKMT2APDCD1CD274HPGD | |
| SCHEMBL21408620 | 0.71 | MEN1 (0.49) | KMT2APDCD1CD274LMNA | |
| SCHEMBL457404 | 0.70 | SMN1; SMN2 (0.36) | PTGS2KDM4EPDCD1CD274HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861365-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | Nycomed GmbH (DE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097474-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | NYCOMED GMBH (DE) | 2006-09-21 | — | — | WO | disclosed |