Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556194 | 0.95 | DPP4 (0.46) | DPP4DPP8DPP9HRH3POLB | |
| SCHEMBL24260232 | 0.83 | DPP4 (0.39) | DPP4DPP8DPP9HRH3FKBP1A | |
| SCHEMBL24260228 | 0.83 | XPNPEP1 (0.40) | DPP4DPP8DPP9HRH3FKBP1A | |
| SCHEMBL22370887 | 0.81 | HRH3 (0.40) | HRH3MAPTPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL22578383 | 0.81 | HRH3 (0.40) | HRH3MAPTPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL25180293 | 0.81 | HRH3 (0.40) | HRH3MAPTPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL18792776 | 0.81 | DPP4 (0.44) | DPP4DPP8DPP9HRH3POLB | |
| Hydrochloric Acid SCHEMBL29654932 | 0.80 | ALDH1A1 (0.40) | HRH3MAPTPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL3083501 | 0.78 | EPHX1 (0.44) | L3MBTL1ALDH1A1HCRTR1HCRTR2KMT2A | |
| SCHEMBL20812666 | 0.77 | OPRD1 (0.49) | DPP4DPP8DPP9POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007066102-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |